A unifying mechanism of DNA translocation underlying chromatin remodeling

L Yan, Z Chen - Trends in biochemical sciences, 2020 - cell.com
Chromatin remodelers alter the position and composition of nucleosomes, and play key
roles in the regulation of chromatin structure and various chromatin-based transactions …

Analysis of individual remodeled nucleosomes reveals decreased histone–DNA contacts created by hSWI/SNF

K Bouazoune, TB Miranda, PA Jones… - Nucleic acids …, 2009 - academic.oup.com
Chromatin remodeling enzymes use the energy of ATP hydrolysis to alter histone–DNA
contacts and regulate DNA-based processes in eukaryotes. Whether different subfamilies of …

Diversity of operation in ATP-dependent chromatin remodelers

SK Hota, B Bartholomew - Biochimica et Biophysica Acta (BBA)-Gene …, 2011 - Elsevier
Chromatin is actively restructured by a group of proteins that belong to the family of ATP-
dependent DNA translocases. These chromatin remodelers can assemble, relocate or …

Targeting chromatin remodelers: signals and search mechanisms

F Erdel, J Krug, G Längst, K Rippe - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
Chromatin remodeling complexes are ATP-driven molecular machines that change
chromatin structure by translocating nucleosomes along the DNA, evicting nucleosomes, or …

Mechanisms for nucleosome movement by ATP-dependent chromatin remodeling complexes

A Saha, J Wittmeyer, BR Cairns - Chromatin Dynamics in Cellular Function, 2006 - Springer
Chromatin remodeling complexes (remodelers) are a set of diverse multi-protein machines
that reposition and restructure nucleosomes. Remodelers are specialized, containing …

Stepwise nucleosome translocation by RSC remodeling complexes

BT Harada, WL Hwang, S Deindl, B Bartholomew… - Biophysical …, 2016 - cell.com
The SWI/SNF family of chromatin-remodeling enzymes are important regulators of chromatin
structure in transcriptional activation and in the creation and maintenance of nucleosome …

Chromatin remodeling by ISW2 and SWI/SNF requires DNA translocation inside the nucleosome

M Zofall, J Persinger, SR Kassabov… - Nature structural & …, 2006 - nature.com
Chromatin-remodeling complexes regulate access to nucleosomal DNA by mobilizing
nucleosomes in an ATP-dependent manner. In this study, we find that chromatin remodeling …

Mechanism (s) of SWI/SNF‐induced nucleosome mobilization

N Liu, A Balliano, JJ Hayes - Chembiochem, 2011 - Wiley Online Library
Impediments to DNA access due to assembly of the eukaryotic genome into chromatin are in
part overcome by the activity of ATP‐dependent chromatin‐remodeling complexes. These …

The mechanisms of action of chromatin remodelers and implications in development and disease

RK Sahu, S Singh, RS Tomar - Biochemical Pharmacology, 2020 - Elsevier
The eukaryotic genetic material is packaged in the form of chromatin by wrapping DNA
around nucleosomes. Cells maintain chromatin in a dynamic state by utilising various ATP …

A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing

HT Dao, BE Dul, GP Dann, GP Liszczak… - Nature chemical …, 2020 - nature.com
Recent studies have implicated the nucleosome acidic patch in the activity of ATP-
dependent chromatin remodeling machines. We used a photocrosslinking-based …