Induction of antigen-specific immune activation by the maturation of dendritic cells (DCs) is a
strategy used for cancer immunotherapy. In this study, we find that FimH, which is an …

Considerable evidence shows that the tumor microenvironment is an active participant in
preventing immunosurveillance and limiting the efficacy of anticancer therapies. Hypoxia is …

Several TLR ligands of bacterial origin induce innate immune responses. Although FimH,
the adhesin portion of type 1 fimbria, plays an important role in the pathogenicity of some …

The clinical efficacy of dendritic cell (DC) vaccine in cancer patients has been unsatisfactory
due, at least in part, to the deficiency of maturation and impaired migration of ex vivo …

Daily treatment of mice with human Flt3 ligand (FL) induces the production of large numbers
of ÌÍÑ-class II+, CDllc+, DEC205+ dendritic cells (DC) in both lymphoid and nonlymphoid …

Commentary to: A new tumor vaccine: FAPτ-MT elicits effective antitumor response by
targeting Indolamine2, 3-dioxygenase in antigen presenting cells Yan-Mei Yi, Ge Zhang …

Effective activation of dendritic cells (DCs) toward T helper (Th)-1 cell polarization would
improve DC-based antitumor immunotherapy, helping promote the development of …

Dendritic cells (DCs) are capable of initiating adaptive immune responses against infectious
agents by presenting pathogen-derived antigens on MHC molecules to naïve T cells …

We have recently shown that systemic administration of low molecular weight hyaluronan
(LMW HA) significantly reduces colorectal carcinoma (CRC) growth in vivo. The elicited …

The tumor microenvironment (TME) polarizes tumor-infiltrating macrophages toward tumor
support. Macrophage-abundant tumors are highly malignant and are the cause of poor …