Immunization with attenuated Plasmodium falciparum sporozoites (PfSPZs) has been shown to be protective against malaria, but the features of the antibody response induced by this …
Abstract Development of a highly effective vaccine or antibodies for the prevention and ultimately elimination of malaria is urgently needed. Here we report the isolation of a number …
G Triller, SW Scally, G Costa, M Pissarev, C Kreschel… - Immunity, 2017 - cell.com
Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of Plasmodium falciparum (Pf) sporozoites, can protect from malaria in animal …
D Oyen, JL Torres, U Wille-Reece… - Proceedings of the …, 2017 - National Acad Sciences
Acquired resistance against antimalarial drugs has further increased the need for an effective malaria vaccine. The current leading candidate, RTS, S, is a recombinant …
Potent and durable vaccine responses will be required for control of malaria caused by Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …
Antibodies against the central repeat of the Plasmodium falciparum (Pf) circumsporozoite protein (CSP) inhibit parasite activity and correlate with protection from malaria. However …
LT Wang, LS Pereira, PK Kiyuka, A Schön… - PLoS …, 2021 - journals.plos.org
Combinations of monoclonal antibodies (mAbs) against different epitopes on the same antigen synergistically neutralize many viruses. However, there are limited studies …
The generation of high-quality antibody responses to Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP), the primary surface antigen of Pf sporozoites, is …
MC Livingstone, AA Bitzer, A Giri, K Luo… - Scientific reports, 2021 - nature.com
Plasmodium falciparum malaria contributes to a significant global disease burden. Circumsporozoite protein (CSP), the most abundant sporozoite stage antigen, is a prime …