Tissue-specific metabolic regulation of FOXO-binding protein: FOXO does not act alone

N Kodani, J Nakae - Cells, 2020 - mdpi.com
The transcription factor forkhead box (FOXO) controls important biological responses,
including proliferation, apoptosis, differentiation, metabolism, and oxidative stress …

Introduction to FOXO biology

W Link - FOXO Transcription Factors: Methods and Protocols, 2019 - Springer
Forkhead box O (FOXO) proteins are a family of transcription factors with four members in
mammals, namely FOXO1, FOXO3a, FOXO4, and FOXO6. FOXO factors, originally identified …

The role of FOXO in the regulation of metabolism

DN Gross, M Wan, MJ Birnbaum - Current diabetes reports, 2009 - Springer
Forkhead box O (FOXO) transcription factors play an important role in modulating metabolic
functions. FOXO is regulated by several modifications, but one of the most critical is …

[HTML][HTML] The FoxO transcription factors and metabolic regulation

J Nakae, M Oki, Y Cao - FEBS letters, 2008 - Elsevier
Forkhead transcription factors FoxOs are conserved beyond species and regulated by
insulin signaling pathway. FoxOs have diverse functions on differentiation, proliferation and …

Adipose tissue and FoxO1: bridging physiology and mechanisms

L Ioannilli, F Ciccarone, MR Ciriolo - Cells, 2020 - mdpi.com
Forkhead box O class proteins (FoxOs) are expressed nearly in all tissues and are involved
in different functions such as energy metabolism, redox homeostasis, differentiation, and cell …

FOXO1: a potential target for human diseases

H Lu, H Huang - Current drug targets, 2011 - ingentaconnect.com
The forkhead box O (FoxO) transcription factors are known to be involved in many
physiological and pathological processes including apoptosis, cell cycle arrest, stress …

The role of FoxO in the regulation of metabolism

DN Gross, APJ Van Den Heuvel, MJ Birnbaum - Oncogene, 2008 - nature.com
Forkhead proteins, and FoxO1 in particular, play a significant role in regulating whole body
energy metabolism. Glucose homeostasis is achieved by adjusting endogenous glucose …

[HTML][HTML] FoxO integration of insulin signaling with glucose and lipid metabolism

S Lee, HH Dong - The Journal of endocrinology, 2017 - ncbi.nlm.nih.gov
The forkhead box O family consists of FoxO1, FoxO3, FoxO4 and FoxO6 proteins in
mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the …

FoxO1 as a tissue-specific therapeutic target for type 2 diabetes

NA Teaney, NE Cyr - Frontiers in Endocrinology, 2023 - frontiersin.org
Forkhead box O (FoxO) proteins are transcription factors that mediate many aspects of
physiology and thus have been targeted as therapeutics for several diseases including …

FoxO proteins in insulin action and metabolism

A Barthel, D Schmoll, TG Unterman - Trends in Endocrinology & Metabolism, 2005 - cell.com
There is increasing evidence that Forkhead box 'Other'(FoxO) proteins, a subgroup of the
Forkhead transcription factor family, have an important role in mediating the effects of insulin …