Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and
polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their …

Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling complexes that
regulate genomic architecture. Here, we present a structural model of the endogenously …

Abstract Mammalian SWI/SNF like Brg1/Brm associated factors (BAF) chromatin-remodeling
complexes are able to use energy derived from adenosine triphosphate (ATP) hydrolysis to …

Over the past 4 years, nearly 100 exome sequencing studies have revealed the high
frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin …

During the last decade, a host of epigenetic mechanisms were found to contribute to cancer
and other human diseases. Several genomic studies have revealed that∼ 20% of …

Summary Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling
complexes are multi-subunit molecular machines that play vital roles in regulating genomic …

Mammalian SWI/SNF chromatin remodelling complexes exist in three distinct, final-form
assemblies: canonical BAF (cBAF), PBAF and a newly characterized non-canonical complex …

DNA wraps around the histone octamer to form nucleosomes, the repeating unit of
chromatin, which create barriers for accessing genetic information. Snf2-like chromatin …

BRG1 and BRM, central components of the BAF (mSWI/SNF) chromatin remodelling
complex, are critical in chromatin structure regulation. Here, we show that the human BRM …

In mammals, combinatorial assembly of alternative families of subunits confers functional
specificity to adenosine triphosphate (ATP)-dependent SWI/SNF-like Brg/Brm-associated …