Structural insights into the evolutionarily conserved BAF chromatin remodeling complex

RD Marcum, AA Reyes, Y He - Biology, 2020 - mdpi.com
The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin
accessibility and plays an essential role in multiple cellular processes. A high frequency of …

The SWI/SNF Complex: A Frequently Mutated Chromatin Remodeling Complex in Cancer

VT Nguyen, M Tessema, BE Weissman - Epigenetics in Oncology, 2023 - Springer
The switch/sucrose non-fermenting (SWI/SNF) chromatin remodeling complex is a global
regulator of gene expression known to maintain nucleosome-depleted regions at active …

A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex

Z Nie, Y Xue, D Yang, S Zhou, BJ Deroo… - … and cellular biology, 2000 - Am Soc Microbiol
The SWI/SNF family of chromatin-remodeling complexes facilitates gene activation by
assisting transcription machinery to gain access to targets in chromatin. This family includes …

BAFfling pathologies: Alterations of BAF complexes in cancer

O Arnaud, F Le Loarer, F Tirode - Cancer letters, 2018 - Elsevier
To activate or repress specific genes, chromatin is constantly modified by chromatin-
remodeling complexes. Among these complexes, the SWItch/Sucrose Non-Fermenting …

Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

C Kadoch, GR Crabtree - Science advances, 2015 - science.org
Over the past 4 years, nearly 100 exome sequencing studies have revealed the high
frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin …

(mis)-Targeting of SWI/SNF complex (es) in cancer

D Reddy, S Bhattacharya, JL Workman - Cancer and Metastasis Reviews, 2023 - Springer
The ATP-dependent chromatin remodeling complex SWI/SNF (also called BAF) is critical for
the regulation of gene expression. During the evolution from yeast to mammals, the BAF …

Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57

J Chen, TK Archer - Molecular and cellular biology, 2005 - Taylor & Francis
The mammalian SWI/SNF chromatin remodeling complex, whose function is of critical
importance in transcriptional regulation, contains approximately 10 protein components. The …

Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex

BR Keppler, TK Archer - Journal of Biological Chemistry, 2010 - ASBMB
The mammalian SWI/SNF chromatin remodeling complex is a key player in multiple
chromatin transactions. Core subunits of this complex, including the ATPase, Brg-1, and …

Modular organization and assembly of SWI/SNF family chromatin remodeling complexes

N Mashtalir, AR D'Avino, BC Michel, J Luo, J Pan… - Cell, 2018 - cell.com
Summary Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling
complexes are multi-subunit molecular machines that play vital roles in regulating genomic …

SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components

I Jung, DH Sohn, J Choi, JM Kim, S Jeon… - Biochemical and …, 2012 - Elsevier
The murine SWI/SNF-like BAF complex is an ATP-dependent chromatin remodeling
complex that functions as a transcriptional regulator in cell proliferation, differentiation and …