Day 7 concentration effects of partner drugs of artemisinin and derivatives on recurrent episodes of uncomplicated Plasmodium falciparum malaria after repetitive …

MM TEKETE - 2020 - archiv.ub.uni-heidelberg.de
The recommendation of artemisinin-based combination therapy (ACT) as a first line
treatment of malaria continues to be based only on data obtained from single episode …

The impact of extended treatment with artemether-lumefantrine on antimalarial exposure and reinfection risks in Ugandan children with uncomplicated malaria: a …

ME Whalen, R Kajubi, J Goodwin… - Clinical Infectious …, 2023 - academic.oup.com
Background Artemether-lumefantrine (AL) is the most widely used artemisinin-based
combination therapy in Sub-Saharan Africa and is threatened by the emergence of …

[HTML][HTML] Repeated artemisinin-based combination therapies in a malaria hyperendemic area of Mali: efficacy, safety, and public health impact

I Sagara, B Fofana, J Gaudart, B Sidibe… - The American journal …, 2012 - ncbi.nlm.nih.gov
Artemisinin-based combination therapies (ACTs) are the first-line treatment of
uncomplicated malaria. The public health benefit and safety of repeated administration of a …

Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: a systematic review and meta-analysis of day 7 lumefantrine concentrations and …

… Resistance Network (WWARN) Lumefantrine PK/PD … - BMC medicine, 2015 - Springer
Background Achieving adequate antimalarial drug exposure is essential for curing malaria.
Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug …

Early variations in plasmodium falciparum dynamics in Nigerian children after treatment with two artemisinin-based combinations: implications on delayed parasite …

OS Michael, GO Gbotosho, OA Folarin, T Okuboyejo… - Malaria journal, 2010 - Springer
Background Combination treatments, preferably containing an artemisinin derivative, are
recommended to improve efficacy and prevent Plasmodium falciparum drug resistance …

Early parasitological response following artemisinin-containing regimens: a critical review of the literature

D Das, RN Price, D Bethell, PJ Guerin, K Stepniewska - Malaria journal, 2013 - Springer
Abstract Background Parasitaemia on Day 3 has been proposed as a useful alert of
potential artemisinin resistance, however, the normal variation of parasite clearance …

Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose …

JLA Ndiaye, B Faye, A Gueye, R Tine, D Ndiaye… - Malaria journal, 2011 - Springer
Background The use of artemisinin-based combination therapy (ACT) is currently
recommended for treating uncomplicated malaria. The objective was to assess the efficacy …

A comparison of the duration of post-treatment protection of artemether-lumefantrine, dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of …

MT Bretscher, JT Griffin, P Hugo, M Baker, A Ghani… - Malaria journal, 2014 - Springer
Background Five artemisinin combination therapies (ACTs) are currently recommended for
treatment of uncomplicated malaria in Africa. Whilst the artemisinin component has a short …

Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda

HH Chang, E Meibalan, J Zelin, R Daniels… - Scientific Reports, 2016 - nature.com
Artemisinin resistance is rapidly spreading in Southeast Asia. The efficacy of artemisinin-
combination therapy (ACT) continues to be excellent across Africa. We performed parasite …

Plasmodium falciparum clearance in clinical studies of artesunate-amodiaquine and comparator treatments in sub-Saharan Africa, 1999–2009

J Zwang, G Dorsey, A Mårtensson, U d'Alessandro… - Malaria Journal, 2014 - Springer
Background Artemisinin-based combination therapy (ACT) is the recommended first-line
therapy for uncomplicated Plasmodium falciparum malaria worldwide but decreased …