Our early-life environment has a profound influence on developing organs that impacts
metabolic function and determines disease susceptibility across the life-course. Using a rat …

The mechanistic causes of aging, the time-related decline in function and good health that
leads to increased mortality, remain poorly understood. Here we propose that age …

Aging involves a progressive decline of metabolic function and an increased incidence of
late-onset degenerative disorders and cancer. To a large extent, these processes are …

Abstract Changes in DNA methylation (DNAm) are linked to aging. Here, we profile highly
conserved CpGs in 339 predominantly female mice belonging to the BXD family for which …

Background Age-associated epigenetic changes are implicated in aging. Notably, age-
associated DNA methylation changes comprise a so-called aging “clock”, a robust …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Aging manifests as progressive deteriorations in homeostasis, requiring systems-level
perspectives to investigate the gradual molecular dysregulation of underlying biological …

Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …

Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

Aging is associated with a wide range of human disorders, including cancer, diabetes,
cardiovascular, and neurodegenerative diseases. Long thought to be an inexorable road …