Histone deacetylases (HDACs) play important roles in transcriptional regulation in
eukaryotic cells. Class I deacetylase HDAC1/2 often associates with repressor complexes …

Histone deacetylases (HDACs) play important roles in regulating cell proliferation and
differentiation. The HDAC1-containing NuRD complex is generally considered as a …

Histone deacetylases (HDACs) are a group of enzymes that catalyze the removal of acetyl
groups from histone and nonhistone proteins. HDACs have been shown to have diverse …

Numerous studies have highlighted the role of post-translational modifications in the
regulation of cell proliferation, differentiation and death. Among these modifications …

Strategies to induce fetal hemoglobin (HbF) synthesis for the treatment of β-
hemoglobinopathies probably involve protein modifications by histone deacetylases …

The transcription factor GATA-1 plays a significant role in erythroid differentiation and
association with CBP stimulates its activity by acetylation. It is possible that histone …

Histone deacetylases (HDACs) are globally implicated in the growth and differentiation of
mammalian cells; however, relatively little is known about their specific roles in …

Histone deacetylase 2 (HDAC2) catalyzes deacetylation of histones at the promoter and
coding regions of transcribed genes and regulates chromatin structure and transcription. To …

Histone acetyltransferases and histone deacetylases (HDACs) are important epigenetic
coregulators. It has been thought that HDACs associate with corepressor complexes and …

Hematopoiesis is a very complex process whose proper functioning requires the regulated
action of a number of transcription factors. Histone acetyltransferases (HATs) and histone …