Decoding the development of the human hippocampus

S Zhong, W Ding, L Sun, Y Lu, H Dong, X Fan, Z Liu… - Nature, 2020 - nature.com
The hippocampus is an important part of the limbic system in the human brain that has
essential roles in spatial navigation and the consolidation of information from short-term …

Molecular architecture of lineage allocation and tissue organization in early mouse embryo

G Peng, S Suo, G Cui, F Yu, R Wang, J Chen, S Chen… - Nature, 2019 - nature.com
During post-implantation development of the mouse embryo, descendants of the inner cell
mass in the early epiblast transit from the naive to primed pluripotent state. Concurrently …

Molecular features driving cellular complexity of human brain evolution

E Caglayan, F Ayhan, Y Liu, RM Vollmer, E Oh… - Nature, 2023 - nature.com
Human-specific genomic changes contribute to the unique functionalities of the human
brain,,,–. The cellular heterogeneity of the human brain, and the complex regulation of gene …

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

A Sahay, KN Scobie, AS Hill, CM O'Carroll… - Nature, 2011 - nature.com
Adult hippocampal neurogenesis is a unique form of neural circuit plasticity that results in
the generation of new neurons in the dentate gyrus throughout life,. Neurons that arise in …

Spatio-temporal transcriptome of the human brain

HJ Kang, YI Kawasawa, F Cheng, Y Zhu, X Xu, M Li… - Nature, 2011 - nature.com
Brain development and function depend on the precise regulation of gene expression.
However, our understanding of the complexity and dynamics of the transcriptome of the …

Wnt signalling regulates adult hippocampal neurogenesis

DC Lie, SA Colamarino, HJ Song, L Désiré, H Mira… - Nature, 2005 - nature.com
The generation of new neurons from neural stem cells is restricted to two regions of the adult
mammalian central nervous system: the subventricular zone of the lateral ventricle, and the …

An anatomically comprehensive atlas of the adult human brain transcriptome

MJ Hawrylycz, ES Lein, AL Guillozet-Bongaarts… - Nature, 2012 - nature.com
Neuroanatomically precise, genome-wide maps of transcript distributions are critical
resources to complement genomic sequence data and to correlate functional and genetic …

Organoid single-cell genomic atlas uncovers human-specific features of brain development

S Kanton, MJ Boyle, Z He, M Santel, A Weigert… - Nature, 2019 - nature.com
The human brain has undergone substantial change since humans diverged from
chimpanzees and the other great apes,. However, the genetic and developmental programs …

[HTML][HTML] Single-cell epigenomics reveals mechanisms of human cortical development

RS Ziffra, CN Kim, JM Ross, A Wilfert, TN Turner… - Nature, 2021 - nature.com
During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

Molecular logic of cellular diversification in the mouse cerebral cortex

DJ Di Bella, E Habibi, RR Stickels, G Scalia, J Brown… - Nature, 2021 - nature.com
The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …