G Peng, S Suo, G Cui, F Yu, R Wang, J Chen, S Chen… - Nature, 2019 - nature.com
During post-implantation development of the mouse embryo, descendants of the inner cell mass in the early epiblast transit from the naive to primed pluripotent state. Concurrently …
Human-specific genomic changes contribute to the unique functionalities of the human brain,,,–. The cellular heterogeneity of the human brain, and the complex regulation of gene …
A Sahay, KN Scobie, AS Hill, CM O'Carroll… - Nature, 2011 - nature.com
Adult hippocampal neurogenesis is a unique form of neural circuit plasticity that results in the generation of new neurons in the dentate gyrus throughout life,. Neurons that arise in …
Brain development and function depend on the precise regulation of gene expression. However, our understanding of the complexity and dynamics of the transcriptome of the …
DC Lie, SA Colamarino, HJ Song, L Désiré, H Mira… - Nature, 2005 - nature.com
The generation of new neurons from neural stem cells is restricted to two regions of the adult mammalian central nervous system: the subventricular zone of the lateral ventricle, and the …
Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources to complement genomic sequence data and to correlate functional and genetic …
S Kanton, MJ Boyle, Z He, M Santel, A Weigert… - Nature, 2019 - nature.com
The human brain has undergone substantial change since humans diverged from chimpanzees and the other great apes,. However, the genetic and developmental programs …
During mammalian development, differences in chromatin state coincide with cellular differentiation and reflect changes in the gene regulatory landscape. In the developing brain …
The mammalian cerebral cortex has an unparalleled diversity of cell types, which are generated during development through a series of temporally orchestrated events that are …