Tetrazanbigen derivatives as peroxisome proliferator-activated receptor gamma (PPARγ) partial agonists: design, synthesis, structure–activity relationship, and …

L Gan, Z Gan, Y Dan, Y Li, P Zhang… - Journal of Medicinal …, 2021 - ACS Publications
Tetrazanbigen (TNBG) is a novel sterol isoquinoline derivative with poor water solubility and
moderate inhibitory effects on human cancer cell lines via lipoapoptosis induction. Herein …

MicroRNA-148a Regulates the Proliferation and Differentiation of Ovine Preadipocytes by Targeting PTEN

X Jin, Z Hao, M Zhao, J Shen, N Ke, Y Song, L Qiao… - Animals, 2021 - mdpi.com
Simple Summary The miR-148a has been shown to play an important role in preadipocyte
differentiation. Herein, we explored the role of miR-148a in ovine adipocyte development …

Novel antiadipogenic effect of menadione in 3T3-L1 cells

MI Funk, MA Conde, G Piwien-Pilipuk… - Chemico-Biological …, 2021 - Elsevier
Inhibition of adipocyte differentiation can be used as a strategy for preventing adipose tissue
expansion and, consequently, for obesity management. Since reactive oxygen species …

Galloyl Group in B-type proanthocyanidin dimers was responsible for its differential inhibitory activity on 3T3-L1 preadipocytes due to the strong lipid raft-perturbing …

R Wang, M Dang, W Zhu, C Li - Journal of Agricultural and Food …, 2021 - ACS Publications
The effects of three B-type proanthocyanidin (PA) dimers covering procyanidin B2 (B-0g),
procyanidin B2 3′-O-gallate (B-1g), and procyanidin B2 3, 3′-di-O-gallate (B-2g) on 3T3 …

Ketogenesis and SIRT1 as a tool in managing obesity

MA Abduraman, NA Azizan, SH Teoh… - Obesity Research & …, 2021 - Elsevier
Obesity is a serious chronic disease and a public health concern in both developing and
developed countries. Managing obesity has been a great challenge for both health care …

Metabolic and transcriptional changes across osteogenic differentiation of mesenchymal stromal cells

TB Sigmarsdottir, S McGarrity, ALG de Lomana… - Bioengineering, 2021 - mdpi.com
Mesenchymal stromal cells (MSCs) are multipotent post-natal stem cells with applications in
tissue engineering and regenerative medicine. MSCs can differentiate into osteoblasts …

Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues

K Ito, M Schneeberger, A Gerber… - Genes & …, 2021 - genesdev.cshlp.org
The MED1 subunit has been shown to mediate ligand-dependent binding of the Mediator
coactivator complex to multiple nuclear receptors, including the adipogenic PPARγ, and to …

Natural Compound 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al from Momordica charantia Acts as PPARγ Ligand

NAA Noruddin, MF Hamzah, Z Rosman, NH Salin… - Molecules, 2021 - mdpi.com
Momordica charantia is a popular vegetable associated with effective complementary and
alternative diabetes management in some parts of the world. However, the molecular …

Peroxisome proliferator‐activated receptor gamma regulates genes involved in milk fat synthesis in mammary epithelial cells of water buffalo

F Zhou, Y Ouyang, Y Miao - Animal Science Journal, 2021 - Wiley Online Library
Peroxisome proliferator‐activated receptor gamma (PPARγ) is a critical transcription factor
regulating lipid and glucose metabolism. However, the regulatory effect of PPARγ on milk fat …

Different expressions of clock genes in fatty liver induced by high-sucrose and high-fat diets

D Li, R Ikaga, H Ogawa, T Yamazaki - Chronobiology International, 2021 - Taylor & Francis
Sucrose consumption can cause obesity and nonalcoholic fatty liver disease (NAFLD).
NAFLD is associated with the disruption of circadian rhythms. We compared the alterations …