Transcriptional differences in lipid-metabolizing enzymes in murine sebocytes derived from sebaceous glands of the skin and preputial glands

K Klas, D Copic, M Direder, M Laggner… - International Journal of …, 2021 - mdpi.com
Sebaceous glands are adnexal structures, which critically contribute to skin homeostasis
and the establishment of a functional epidermal barrier. Sebocytes, the main cell population …

[HTML][HTML] Browning Effect of Brominated Flame Retardant, TBBP-A, on Undifferentiated Adipocytes

M Yamasaki, S Hasegawa, M Imai, T Fukui… - BPB Reports, 2021 - jstage.jst.go.jp
Recent studies have suggested that exposure to brominated flame retardants (BFR) may
play a pivotal role in the development of high-fat diet-induced obesity and metabolic …

Lack of Adiponectin Drives Hyperosteoclastogenesis in Lipoatrophic Mice

MB Madel, H Fu, DD Pierroz, M Schiffrin… - Frontiers in cell and …, 2021 - frontiersin.org
Long bones from mammals host blood cell formation and contain multiple cell types,
including adipocytes. Physiological functions of bone marrow adipocytes are poorly …

Feprazone Displays Antiadipogenesis and Antiobesity Capacities in in Vitro 3 T3-L1 Cells and in Vivo Mice

L Che, B Ren, Y Jia, Y Dong, Y Wang, J Shan… - ACS …, 2021 - ACS Publications
Background and purpose: Excessive lipid accumulation in adipose tissues and deregulation
of adipogenesis-induced obesity affect millions of people worldwide. Feprazone, a …

Partial deficiency of Zfp217 resists high-fat diet-induced obesity by increasing energy metabolism in mice

Q Zeng, N Wang, Y Zhang, Y Yang, S Li… - International Journal of …, 2021 - mdpi.com
Obesity-induced adipose tissue dysfunction and disorders of glycolipid metabolism have
become a worldwide research priority. Zfp217 plays a crucial role in adipogenesis of 3T3-L1 …

Determination of oxidized lipids in commonly consumed foods and a preliminary analysis of their binding affinity to PPARγ

J Skinner, P Arora, N McMath, M Penumetcha - Foods, 2021 - mdpi.com
Foods rich in poly unsaturated fatty acids (PUFA) are vulnerable to oxidation. While it is well
established that endogenously derived oxidized lipids are ligands of the transcription factor …

The B56α subunit of PP2A is necessary for mesenchymal stem cell commitment to adipocyte

EA Hanse, M Pan, W Liu, Y Yang, MB Ishak Gabra… - EMBO …, 2021 - embopress.org
Adipose tissue plays a major role in maintaining organismal metabolic equilibrium. Control
over the fate decision from mesenchymal stem cells (MSCs) to adipocyte differentiation …

Effects of KY-903, a Novel Tetrazole-Based Peroxisome Proliferator-Activated Receptor γ Modulator, in Male Diabetic Mice and Female Ovariectomized Rats

Y Ito, M Yamamoto, S Furukawa, M Fukui… - Biological and …, 2021 - jstage.jst.go.jp
Peroxisome proliferator-activated receptor γ (PPARγ) modulators are expected to exert anti-
diabetic effects without PPARγ-related adverse effects, such as fluid retention, weight gain …

HGFAC is a ChREBP regulated hepatokine that enhances glucose and lipid homeostasis

A Sargsyan, L Doridot, SA Hannou, W Tong… - bioRxiv, 2021 - biorxiv.org
Abstract Carbohydrate Responsive Element-Binding Protein (ChREBP) is a carbohydrate
sensing transcription factor that regulates both adaptive and maladaptive genomic …

Fucoidans from Thelenota ananas with 182.4 kDa Exhibited Optimal Anti-Adipogenic Activities by Modulating the Wnt/β-Catenin Pathway

Y Liu, N Wang, Y Tian, Y Chang, J Wang - Journal of Ocean University of …, 2021 - Springer
In this study, fucoidans were extracted from the sea cucumber Thelenota ananas (Ta-FUCs)
by enzymatic degradation. Four products with molecular weights of 1380.3, 524.0, 182.4 …