Class B1 metallo-β-lactamases (MBLs) are metalloenzymes found in drug resistant bacteria.
The enzyme requires zinc ions, along with conserved amino acid coordination for …

To analyze the drug-resistant phenotype and genetic characteristics of Carbapenem
resistant Klebsiella pneumoniae (CRKP) in this region, and to study its different expression …

The development and spread of antibiotic-resistant bacteria are now recognised as a key
threat to our community, public health and domestic animal. A small number of antibiotics …

The synthesis of a series of compounds designed to act as inhibitors of metallo-β-lactamase
enzymes (MBLs), a sub-class of β-lactamases found in several clinically difficult to treat …

Antibiotics are essential for modern medicine and as antibiotics are now becoming
increasingly ineffective, effective treatment of an ever-increasing range of infections is …

Metalloenzymes, enzymes that utilise a metal ion within their active site for their enzymatic
activity, make up a significant portion of known enzymes. In fact, literature suggests that …

Potenciālu β-laktamāžu inhibitoru sintēze ciklisko borskābju esteru klasē. Parkova A.,
zinātniskais vadītājs Dr. chem. Trapencieris P. Promocijas darbs, 156 lappuses, 63 attēli, 6 …

Zn2+, Ca2+ and Mg2+ were assessed by using isothermal titration calorimetry (ITC). We
also compared the ability of the different inhibitors to resensitize a highly resistant MBL …