Microfluidics for development of lipid nanoparticles: paving the way for nucleic acids to the clinic
Nucleic acid therapeutics hold an unprecedented promise toward treating many challenging
diseases; however, their use is hampered by delivery issues. Microfluidics, dealing with …
diseases; however, their use is hampered by delivery issues. Microfluidics, dealing with …
Gene therapy for polyglutamine spinocerebellar ataxias: advances, challenges, and perspectives
Y Vázquez‐Mojena, K León‐Arcia… - Movement …, 2021 - Wiley Online Library
Polyglutamine spinocerebellar ataxias (SCAs) comprise a heterogeneous group of six
autosomal dominant ataxias caused by cytosine–adenine–guanine repeat expansions in …
autosomal dominant ataxias caused by cytosine–adenine–guanine repeat expansions in …
Inhalation delivery technology for genome-editing of respiratory diseases
The clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-
associated protein 9 (CRISPR/Cas9) system has significant therapeutic potentials for lung …
associated protein 9 (CRISPR/Cas9) system has significant therapeutic potentials for lung …
Recent development of gene therapy for pancreatic cancer using non-viral nanovectors
Y Liu, W Wu, Y Wang, S Han, Y Yuan, J Huang… - Biomaterials …, 2021 - pubs.rsc.org
Pancreatic cancer (PC), characterized by its dense desmoplastic stroma and
hypovascularity, is one of the most lethal cancers with a poor prognosis in the world …
hypovascularity, is one of the most lethal cancers with a poor prognosis in the world …
Gene therapy strategies for idiopathic pulmonary fibrosis: recent advances, current challenges, and future directions
Idiopathic pulmonary fibrosis (IPF) is a chronic disease in which the lungs become
irreversibly scarred, leading to declining lung function. As currently available drugs do not …
irreversibly scarred, leading to declining lung function. As currently available drugs do not …
Advances in siRNA delivery strategies for the treatment of MDR cancer
RNA interference (RNAi) represents a promising therapeutic method that uses siRNA for
cancer treatment. Although the RNAi technique has been increasingly used for clinical trials …
cancer treatment. Although the RNAi technique has been increasingly used for clinical trials …
RNA-based therapeutics: current developments in targeted molecular therapy of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a highly heterogeneous and aggressive cancer that
has the highest mortality rate out of all breast cancer subtypes. Conventional clinical …
has the highest mortality rate out of all breast cancer subtypes. Conventional clinical …
Biomedical and tissue engineering strategies to control foreign body reaction to invasive neural electrodes
M Gori, G Vadalà, SM Giannitelli, V Denaro… - … in Bioengineering and …, 2021 - frontiersin.org
Neural-interfaced prostheses aim to restore sensorimotor limb functions in amputees. They
rely on bidirectional neural interfaces, which represent the communication bridge between …
rely on bidirectional neural interfaces, which represent the communication bridge between …
Cross-kingdom regulation by dietary plant miRNAs: an evidence-based review with recent updates
MX Jia, JT He, WD Bai, QL Lin, J Deng, W Li, J Bai… - Food & Function, 2021 - pubs.rsc.org
As non-coding RNA molecules, microRNAs (miRNAs) are widely known for their critical role
in gene regulation. Recent studies have shown that plant miRNAs obtained through dietary …
in gene regulation. Recent studies have shown that plant miRNAs obtained through dietary …
Cell-penetrating peptides delivering siRNAs: an overview
Abstract Cell-Penetrating Peptides (CPP) are valuable tools capable of crossing the plasma
membrane to deliver therapeutic cargo inside cells. Small interfering RNAs (siRNA) are …
membrane to deliver therapeutic cargo inside cells. Small interfering RNAs (siRNA) are …