The biological understanding of RNA has evolved since the discovery of catalytic RNAs in
the early 1980s and the establishment of RNA interference (RNAi) in the 1990s. RNA is no …

Advances in understanding disease pathogenesis correlates to modifications in gene
expression within different tissues and organ systems. In depth knowledge about the …

Although the study of ribonucleic acid (RNA) therapeutics started decades ago, for many
years, this field of research was overshadowed by the growing interest in DNA-based …

Pseudogenes were once considered as “junk DNA”, due to loss of their functions as a result
of the accumulation of mutations, such as frameshift and presence of premature stop-codons …

CRISPR/Cas9-based technology has revolutionized biomedical research by providing a
high-fidelity gene-editing method, foreshadowing a significant impact on the therapeutics of …

Despite significant efforts, there are currently no approved treatments for COVID-19.
However, biotechnological approaches appear to be promising in the treatment of the …

Triple negative breast cancer (TNBC) is one of the most aggressive form of breast cancer. It
is characterized by the absence of estrogen, progesterone and human epidermal growth …

Engineering of cellular biomolecules is an emerging landscape presenting creative
therapeutic opportunities. Recently, several strategies such as biomimetic materials, drug …

RNA therapeutics is a rapidly emerging field of biotherapeutics based upon a powerful and
versatile platform with a nearly unlimited capacity to address unmet clinical needs. These …

Precise control of gene expression is critical for biological research and biotechnology.
However, transient plasmid transfections in mammalian cells produce a wide distribution of …