Emerging therapeutics in Huntington's disease

R Wiggins, A Feigin - Expert Opinion on Emerging Drugs, 2021 - Taylor & Francis
Introduction Huntington's disease is a neurodegenerative disease that is characterized by
motor dysfunction, behavioral/psychiatric symptoms, and cognitive impairment. Because of …

A review on the evolving roles of MiRNA-based technologies in diagnosing and treating heart failure

PJ Kennel, PC Schulze - Cells, 2021 - mdpi.com
MiRNA-regulated processes are pivotal in cardiovascular homeostasis and disease. These
short non-coding RNAs have ideal properties that could be utilized as potential biomarkers; …

MicroRNAs and oxidative stress: an intriguing crosstalk to be exploited in the management of type 2 diabetes

T Vezza, AM de Marañón, F Canet, P Díaz-Pozo… - Antioxidants, 2021 - mdpi.com
Type 2 diabetes is a chronic disease widespread throughout the world, with significant
human, social, and economic costs. Its multifactorial etiology leads to persistent …

Pharmacological targets and emerging treatments for respiratory syncytial virus bronchiolitis

F Elawar, AK Oraby, Q Kieser, LD Jensen… - Pharmacology & …, 2021 - Elsevier
RSV infection of the lower respiratory tract in infants is the leading cause of pediatric
hospitalizations and second to malaria in causing infant deaths worldwide. RSV also causes …

A computational approach on studying the regulation of TGF-β1-stimulated Runx2 expression by MicroRNAs in human breast cancer cells

S Pranavkrishna, G Sanjeev, RL Akshaya… - Computers in Biology …, 2021 - Elsevier
Background Transforming growth factor-beta1 (TGF-β1) acts as a most effective growth
inhibitor for normal epithelial cells. Loss of this anti-proliferative factor in breast tissues …

Protective effects of dexmedetomidine on cerebral ischemia/reperfusion injury via the microRNA-214/ROCK1/NF-κB axis

W Liu, C Shao, C Zang, J Sun, M Xu, Y Wang - BMC anesthesiology, 2021 - Springer
Background Cerebral ischemia/reperfusion injury (CIRI) is a complication of surgical
procedure associated with high mortality. The protective effect of dexmedetomidine (DEX) …

miR-942-5p promotes the proliferation and invasion of human melanoma cells by targeting DKK3

W Zhang, K Mao, S Liu, Y Xu, J Ren - Journal of Receptors and …, 2021 - Taylor & Francis
Objective The purpose of this study was to figure out the dysregulation of miR-942-5p in
melanoma and its role in melanoma pathogenesis. Methods Quantitative real-time PCR …

New RNA-based breakthroughs in Alzheimer's disease diagnosis and therapeutics

M Riscado, B Baptista, F Sousa - Pharmaceutics, 2021 - mdpi.com
Dementia is described as the fifth leading cause of death worldwide and Alzheimer's
disease (AD) is recognized as the most common, causing a huge impact on health costs and …

The potential role of miRNA therapies in spinal muscle atrophy

G Gandhi, S Abdullah, AI Foead, WWY Yeo - Journal of the Neurological …, 2021 - Elsevier
Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by low levels of full-
length survival motor neuron (SMN) protein due to the loss of the survival motor neuron 1 …

Cytocompatibility, membrane disruption, and siRNA delivery using environmentally responsive cationic nanogels

DS Spencer, AB Shodeinde, DW Beckman… - Journal of Controlled …, 2021 - Elsevier
Advances in the formulation of nucleic acid-based therapeutics have rendered them a
promising avenue for treating diverse ailments. Nonetheless, clinical translation of these …