An approach called cell-free therapy has rapidly developed in regenerative medicine over
the past decade. Understanding the molecular mechanisms and signaling pathways …

Simple Summary While the importance of transforming growth factor β (TGFβ) in cancer
development and progression has long been recognized, a successful therapy targeting this …

Objective Osteosarcoma (OS) is the most common malignant bone tumor in the pediatric
population. The main goal of this study is to investigate the role of hsa_circ_0005909 and …

Gastric cancer is one of the leading types of cancer with an annual death toll of 700,000
worldwide. Despite the fact that several agents are approved for its treatment, high …

Neurodegenerative disorders, ischemic brain diseases, and brain tumors are debilitating
diseases that severely impact a person's life and could possibly lead to their demise if left …

RNA is essential for cellular function: From sensing intra-and extracellular signals to
controlling gene expression, RNA mediates a diverse and expansive list of molecular …

A wide spectrum of genetic and epigenetic variations together with environmental factors
has made colorectal cancer (CRC), which involves the colon and rectum, a challenging and …

Hyperglycemia is the hallmark of T2DM, related to many candidate genes, eg, MAPK4,
GCKR, STAT3, SOCS3, PTPN1 and PEPCK. To detect new variants of the susceptible …

Therapeutic small interfering RNAs (siRNAs) are double stranded RNAs capable of potent
and specific gene silencing through activation of the RNA interference (RNAi) pathway. The …

Matrix metalloproteinases (MMPs) cleave extracellular matrix proteins, growth factors,
cytokines, and receptors to influence organ development, architecture, function, and the …