Major depressive disorder (MDD) has been shown to be associated with structural
abnormalities in a variety of spatially diverse brain regions. However, the correlation …

Technological and data sharing advances have led to a proliferation of high-resolution
structural and functional maps of the brain. Modern neuroimaging research increasingly …

Postmortem studies have revealed increased density of excitatory synapses in the brains of
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …

Through harmonized procedures and by sharing site-specific brain metrics (for example,
cortical thickness) or aggregated statistical maps, ENIGMA has set the stage for large-scale …

Regulation of gene expression drives protein interactions that govern synaptic wiring and
neuronal activity. The resulting coordinated activity among neuronal populations supports …

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed
whole-genome sequencing in large cohorts of LBD cases and neurologically healthy …

Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …

Human brain organoids represent remarkable platforms for recapitulating features of human
brain development and diseases. Existing organoid models do not resolve fine brain …

Importance Large-scale neuroimaging studies have revealed group differences in cortical
thickness across many psychiatric disorders. The underlying neurobiology behind these …

Large-scale biophysical circuit models provide mechanistic insights into the micro-scale and
macro-scale properties of brain organization that shape complex patterns of spontaneous …