Effect of colchicine vs usual care alone on intubation and 28-day mortality in patients hospitalized with COVID-19: a randomized clinical trial

R Diaz, A Orlandini, N Castellana, A Caccavo… - JAMA network …, 2021 - jamanetwork.com
Importance Hospitalized patients with COVID-19 pneumonia have high rates of morbidity
and mortality. Objective To assess the efficacy of colchicine in hospitalized patients with …

[HTML][HTML] Association of prehospital antiplatelet therapy with survival in patients hospitalized with COVID‐19: A propensity score‐matched analysis

JH Chow, Y Yin, DP Yamane, D Davison… - Journal of Thrombosis …, 2021 - Elsevier
Abstract Purpose Coronavirus disease 2019 (COVID‐19) is associated with
hypercoagulability and increased thrombotic risk. The impact of prehospital antiplatelet …

Colchicine in recently hospitalized patients with COVID-19: a randomized controlled trial (COL-COVID)

DA Pascual-Figal, AE Roura-Piloto… - … Journal of General …, 2021 - Taylor & Francis
Background Colchicine has been proposed as a potential therapy in coronavirus disease
2019 (COVID-19) due to their anti-inflammatory actions. Methods The COL-COVID study …

Pathogenic basis of thromboinflammation and endothelial injury in COVID-19: current findings and therapeutic implications

Y Higashikuni, W Liu, T Obana, M Sata - International Journal of …, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a global pandemic with a great impact on social …

The impact of therapeutics on mortality in hospitalised patients with COVID-19: systematic review and meta-analyses informing the European Respiratory Society …

ML Crichton, PC Goeminne, K Tuand… - European …, 2021 - Eur Respiratory Soc
Hospitalised patients with coronavirus disease 2019 (COVID-19) have a high mortality rate.
There are an increasing number of published randomised controlled trials for anti …

Persistent SARS-CoV-2 infection: the urgent need for access to treatment and trials

E Moran, T Cook, AL Goodman, RK Gupta… - The Lancet Infectious …, 2021 - thelancet.com
The management of patients presenting to healthcare services with SARS-CoV-2 infection
has developed rapidly over the past year, driven by the findings of high-quality randomised …

COVID-19 and X-linked agammaglobulinemia (XLA)–insights from a monogenic antibody deficiency

MJ Ponsford, BMJ Shillitoe, IR Humphreys… - Current Opinion in …, 2021 - journals.lww.com
In contrast to reports made early in the pandemic, we show XLA patients remain susceptible
to severe disease. Persistent infection was common and is likely to carry a significant …

SARS-CoV-2 B. 1.617. 2 Delta variant emergence, replication and sensitivity to neutralising antibodies

P Mlcochova, S Kemp, MS Dhar, G Papa, B Meng… - BioRxiv, 2021 - biorxiv.org
Abstract The SARS-CoV-2 B. 1.617. 2 (Delta) variant was first identified in the state of
Maharashtra in late 2020 and spread throughout India, displacing the B. 1.1. 7 (Alpha) …

Repurposing colchicine in treating patients with COVID-19: a systematic review and meta-analysis

CH Lien, MD Lee, SL Weng, CH Lin, LYM Liu, YL Tai… - Life, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19) had caused huge health losses worldwide. Several
drugs had been applied to treat patients with COVID-19, and repurposing colchicine had …

SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection

AE Chaouat, H Achdout, I Kol, O Berhani, G Roi… - PLoS …, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the
COVID-19 pandemic. Currently, as dangerous mutations emerge, there is an increased …