Abstract Uromodulin, also named Tamm Horsfall protein, have been associated with renal
function and sodium homeostasis regulation. The authors sought to examine the effects of …

Background: Uromodulin, also named Tamm Horsfall protein, has been associated with
renal function and regulation of sodium homeostasis. We aimed to examine the associations …

BACKGROUND Uromodulin modulates the sodium-potassium-two-chloride transporter in
the thick ascending limb of the loop of Henle, and its overexpression in murine models leads …

BACKGROUND: Uromodulin regulates activity of the sodium-potassium-two-chloride
transporter in the loop of Henle. In adults, higher urine uromodulin levels are associated with …

Uromodulin is a key protein involved in the risk of CKD and hypertension, essentially
produced by the cells lining the thick ascending limb of the loop of Henle (1). Uromodulin …

Novel findings have shown a link between the genetic susceptibility to salt-sensitive
hypertension and chronic kidney disease (CKD) and the level of uromodulin expression …

Uromodulin (UMOD) is the most abundant renal protein secreted into urine by the thick
ascending limb (TAL) epithelial cells of the loop of Henle. Genetic studies have …

A recent genome-wide association study identified a locus on chromosome 16 in the
promoter region of the uromodulin (UMOD) gene that is associated with hypertension. Here …

The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

Background: Uromodulin is the most abundant protein in urine. Low uromodulin has been
found associated with diabetes as well as with chronic kidney disease (CKD). Whether it …