Simple Summary The kynurenine pathway (KP) is a biochemical pathway that synthesizes
the vital coenzyme, nicotinamide adenine dinucleotide (NAD+). In cancer, the KP is …

Breast cancer (BrCa) is the leading cause of cancer incidence and mortality in women
worldwide. While BrCa treatment has been shown to be highly successful if detected at an …

Simple Summary The kynurenine pathway has two main physiological roles:(i) it protects
specific organs such as the eyes and placenta from strong immune reactions and (ii) it …

The term “immune privilege” was originally coined to describe the suppression of
inflammatory responses within organs protected by anatomic barriers, ie, the eyes, brain …

The Catabolism of tryptophan modulates the immunosuppressive microenvironment in
tumors. KYNU (Kynureninase) served as an enzyme involved in amino acid tryptophan …

Background. Kynureninase (KYNU) is a potential prognostic marker for various tumor types.
However, no reports on the biological effects and prognostic value of KYNU in gastric cancer …

The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading
to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and …

The kynurenine pathway (KP) and associated catabolites play key roles in promoting tumor
progression and modulating the host anti-tumor immune response. To date, considerable …

Breast cancer (BrCa) is the leading cause of cancer related death in women. While current
diagnostic modalities provide opportunities for early medical intervention, significant …

Background Immunotherapy has recently been proposed as a promising treatment to stop
breast cancer (BrCa) progression and metastasis. However, there has been limited success …