Xenoextracellular matrix-rosiglitazone complex-mediated immune evasion promotes xenogenic bioengineered root regeneration by altering M1/M2 macrophage …

T Lan, J Chen, J Zhang, F Huo, X Han, Z Zhang, Y Xu… - Biomaterials, 2021 - Elsevier
Xenogenic extracellular matrix (xECM)-based organ transplantation will be a promising
approach to address the problem of donor shortage for allotransplantation, which has …

[HTML][HTML] Recruited CD68+ CD206+ macrophages orchestrate graft immune tolerance to prompt xenogeneic-dentin matrix-based tooth root regeneration

H Li, J Sun, H Yang, X Han, X Luo, LJ Liao, B Yang… - Bioactive materials, 2021 - Elsevier
Successful regenerative medicine strategies of xenogeneic extracellular matrix need a
synergistic balance among inflammation, fibrosis, and remodeling process. Adaptive …

[HTML][HTML] PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress

T Lan, F Bi, Y Xu, X Yin, J Chen, X Han… - International Journal of …, 2023 - nature.com
Xenogenic organ transplantation has been considered the most promising strategy in
providing possible substitutes with the physiological function of the failing organs as well as …

Xenogeneic native decellularized matrix carrying PPARγ activator RSG regulating macrophage polarization to promote ligament-to-bone regeneration

X Han, L Liao, T Zhu, Y Xu, F Bi, L Xie, H Li… - Materials Science and …, 2020 - Elsevier
Host immune response to tissue engineering tissues or organs directly determines the graft
survival and the integration with host. Our and other previous studies have successfully …

[HTML][HTML] Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the …

H Fu, L Sen, F Zhang, S Liu, M Wang, H Mi… - Journal of …, 2023 - Springer
Xenogeneic extracellular matrices (xECM) for cell support have emerged as a potential
strategy for addressing the scarcity of donor matrices for allotransplantation. However, the …

Mesenchymal stromal exosome–functionalized scaffolds induce innate and adaptive immunomodulatory responses toward tissue repair

N Su, Y Hao, F Wang, W Hou, H Chen, Y Luo - Science advances, 2021 - science.org
Designing scaffolds capable of inducing and guiding appropriate immune responses holds
promise for tissue repair/regeneration. Biofunctional scaffolds were here prepared by …

Autologous cell membrane coatings on tissue engineering xenografts for suppression and alleviation of acute host immune responses

C Tao, X Nie, W Zhu, J Iqbal, C Xu, DA Wang - Biomaterials, 2020 - Elsevier
Xenogeneic extracellular matrix (ECM) based tissue engineering graft is one of the most
promising products for transplantation therapies, which could alleviate the pain of patients …

Immunogenicity in xenogeneic scaffold generation: antigen removal vs. decellularization

ML Wong, LG Griffiths - Acta biomaterialia, 2014 - Elsevier
Decades of research have been undertaken towards the goal of tissue engineering using
xenogeneic scaffolds. The primary advantages associated with use of xenogeneic tissue …

Decellularization‐Based Modification Strategy for Bioactive Xenografts Promoting Tendon Repair

H Jin, Y Kang, H Gao, Z Lin, D Huang… - Advanced …, 2024 - Wiley Online Library
Xenografts have emerged as a promising option for severe tendon defects treatment.
However, despite undergoing decellularization, concerns still remain regarding the …

Highly Bioactive MXene-M2-Exosome Nanocomposites Promote Angiogenic Diabetic Wound Repair through Reconstructing High Glucose-Derived Immune Inhibition

X Jiang, J Ma, K Xue, J Chen, Y Zhang, G Zhang… - ACS …, 2024 - ACS Publications
The repair of diabetic wounds remains challenging, primarily due to the high-glucose-
derived immune inhibition which often leads to the excessive inflammatory response …