Objectives: Using a PC12 cell model with Hydrogen peroxide, we investigated the neuronal
apoptotic gene expression and neuronal apoptosis after oxidative stress damage. We further …

To the best of our knowledge, the role of peroxisome proliferator‑activated receptor γ
(PPARγ) in oxidative stress‑induced PC12 cell damage is unknown. Using a PC12 cell …

Objective To investigate whether H₂O₂treatment negatively regulates PPARγ in primary
cortical neurons by increasing PPARγ phosphorylation. Methods Primary cultured cortical …

Oxidative stress can lead to expression of inflammatory transcription factors, which are
important regulatory elements in the induction of inflammatory responses. One of the …

OBJECTIVE: In order to investigate the potential mechanisms in troglitazone-induced
apoptosis in HT29 cells, the effects of PPARγ and POX-induced ROS were explored …

Tert-butyl hydroperoxide (t-BHP) can induce cell injury by forming free radical intermediates.
Peroxisome proliferator-activated receptor (PPAR)-γ is a ligand-activated transcription factor …

Aims The worldwide increase in aging population is prevalently associated with the increase
of neurodegenerative diseases. Peroxisome Proliferator-Activated Receptors (PPARs) are …

Oxidative stress has been implicated as a major mechanism underlying the pathogenesis of
neurodegenerative disorders. ROS (reactive oxygen species) can cause cell death via …

Oxidative stress serves an important role in hypertensive brain damage. Peroxisome
proliferator‑activated receptor γ (PPAR‑γ) agonists possess antioxidative and anti‑apoptotic …

Objective To investigate the apoptotic effects of peroxisome proliferator-activated receptor γ
(PPAR-γ) agonist rosiglitazone (RGZ) on leukemia HL-60 cells. Methods Cell apoptosis was …