The endoplasmic reticulum (ER) is the site of protein folding and secretion, Ca2+ storage
and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in …

The endoplasmic reticulum (ER) plays a crucial role in protein folding, assembly, and
secretion. Disruption of ER homeostasis may lead to accumulation of misfolded or unfolded …

Protein folding homeostasis in the lumen of the endoplasmic reticulum is defended by signal
transduction pathways that are activated by an imbalance between unfolded proteins and …

The unfolded protein response (UPR) is classically viewed as a stress response pathway to
maintain protein homeostasis at the endoplasmic reticulum (ER). However, it has recently …

The unfolded protein response (UPR) is an adaptive stress response that responds to the
accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) and that …

The unfolded protein response (UPR) is activated by endoplasmic reticulum (ER) stress and
is designed to restore cellular homeostasis through multiple intracellular signalling …

The endoplasmic reticulum (ER) is a central organelle for protein biosynthesis, folding, and
traffic. Perturbations in ER homeostasis create a condition termed ER stress and lead to …

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of
homeostasis causes stress. In this review I summarize how perturbation of three major …

The endoplasmic reticulum (ER) is the cellular organelle responsible for protein folding and
assembly, lipid and sterol biosynthesis, and calcium storage. The unfolded protein response …