Background Polygenic risk scores (PRSs) can stratify populations into cardiovascular
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …

Importance The clinical utility of polygenic risk scores (PRS) for coronary artery disease
(CAD) has not yet been established. Objective To investigate the ability of a CAD PRS to …

Background: Both lifestyle and genetic factors confer risk for cardiovascular diseases, type 2
diabetes, and dyslipidemia. However, the interactions between these 2 groups of risk factors …

Cardiometabolic diseases contribute more to global morbidity and mortality than any other
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …

Background Cardiovascular diseases are the leading cause of death in the United States,
yet a significant proportion of adults at high risk remain undetected by standard screening …

Background Several polygenic risk scores (PRS) have been developed for cardiovascular
risk prediction, but the additive value of including PRS together with conventional risk factors …

Aims To construct a polygenic risk score (PRS) for coronary artery disease (CAD) and
comprehensively evaluate its potential in clinical utility for primary prevention in Chinese …

Importance The incremental value of polygenic risk scores in addition to well-established
risk prediction models for coronary artery disease (CAD) is uncertain. Objective To examine …

Background: Individual risk prediction based on genome-wide polygenic risk scores (PRSs)
using millions of genetic variants has attracted much attention. It is under debate whether …

Background Polygenic risk scores (PRS) for coronary artery disease (CAD) identify high-risk
individuals more likely to benefit from primary prevention statin therapy. Whether polygenic …