Energy metabolism plays an important role in proliferating cells. Recent reports indicate that
metabolic regulation or metabolic products can control immune cell differentiation, fate and …

Emerging reports show that metabolic pathways can be targeted to enhance T cell-mediated
immunity to tumors. Yet, tumors consume key metabolites in the host to survive, thus robbing …

Through the successes of checkpoint blockade and adoptive cellular therapy,
immunotherapy has become an established treatment modality for cancer. Cellular …

Simple Summary In a tumor context, antitumor immune cells mediate an inflammatory
response after activating a metabolic switch to kill cancer cells. However, tumors develop …

There has been significant progress in utilizing our immune system against cancer, mainly
by checkpoint blockade and T cell-mediated therapies. The field of cancer immunotherapy is …

Immune checkpoint inhibitor (ICI) therapy has shown extraordinary promise at treating
cancers otherwise resistant to treatment. However, for ICI therapy to be effective, it must …

Immune checkpoint inhibitors (ICIs) have shown promising therapeutic effects in the
treatment of advanced solid cancers, but their overall response rate is still very low for …

In recent decades, immunotherapy has emerged as a groundbreaking approach in cancer
treatment, offering new hope for patients. However, its efficacy remains limited due to low …

Immunotherapy has revolutionized cancer treatment and revitalized efforts to harness the
power of the immune system to combat a variety of cancer types more effectively. However …

Immunotherapy, especially PD-1/PD-L1 checkpoint blockade immunotherapy, has led tumor
therapy into a new era. However, the vast majority of patients do not benefit from …