The incidence of autoimmune disease is increasing worldwide. Current treatments for
autoimmune disease are often life-long and associated with general immunosuppression …

Macrophage-mediated inflammation drives autoimmune and chronic inflammatory diseases.
Treatment with anti-inflammatory agents can be an effective strategy to reduce this …

Introduction Tolerogenic Dendritic Cells (tolDCs) have an exceptional promise as a potential
therapy for autoimmune disease and transplantation rejection. TolDCs are a unique …

Glucocorticoids (GCs) are efficacious drugs used for treating many inflammatory diseases,
but the dose and duration of administration are limited because of severe side effects. We …

Some of the studies employing non-antigenic, non-allergenic and tolerogenic derivatives of
antigens and allergens, synthesized by coupling onto them an optimal number (n) of …

We describe the discovery of a thioester-containing glucocorticoid receptor modulator
(GRM) payload and the corresponding antibody–drug conjugate (ADC). Payload 6 was …

Immunomodulatory agents represent one of the most promising strategies for enhancing
tissue regeneration without the side effects of traditional drug-based therapies. Tissue repair …

Inflammation is a protective immune response against invading pathogens, however,
dysregulated inflammation is detrimental. As the complex inflammatory response involves …

Emerging immunotherapeutics for immune activation and tolerance | Drug Delivery and
Translational Research Skip to main content SpringerLink Account Menu Find a journal Publish …

In recent years target based drug discovery has expanded our therapeutic armamentarium
in the treatment of inflammatory and autoimmune diseases. Despite these advances and …