[HTML][HTML] mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity
Postmortem studies have revealed increased density of excitatory synapses in the brains of
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …
[HTML][HTML] Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
Multiple autism risk genes converge on the regulation of mTOR signalling, which is a key
effector of neuronal growth and connectivity. We show that mTOR signalling is dysregulated …
effector of neuronal growth and connectivity. We show that mTOR signalling is dysregulated …
[HTML][HTML] Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits
Developmental alterations of excitatory synapses are implicated in autism spectrum
disorders (ASDs). Here, we report increased dendritic spine density with reduced …
disorders (ASDs). Here, we report increased dendritic spine density with reduced …
Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase
Local hyperconnectivity in the neocortex is a hypothesized pathophysiological state in
autism spectrum disorder (ASD). MET, a receptor tyrosine kinase that regulates dendrite and …
autism spectrum disorder (ASD). MET, a receptor tyrosine kinase that regulates dendrite and …
[HTML][HTML] Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes
Abstract Autism Spectrum Disorder (ASD) is characterized by substantial, yet highly
heterogeneous abnormalities in functional brain connectivity. However, the origin and …
heterogeneous abnormalities in functional brain connectivity. However, the origin and …
Patients with autism spectrum disorders display reproducible functional connectivity alterations
Despite the high clinical burden, little is known about pathophysiology underlying autism
spectrum disorder (ASD). Recent resting-state functional magnetic resonance imaging (rs …
spectrum disorder (ASD). Recent resting-state functional magnetic resonance imaging (rs …
[HTML][HTML] Atypical functional connectome hierarchy in autism
One paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-
cognitive processing. Here, we examined whether these phenotypical patterns may relate to …
cognitive processing. Here, we examined whether these phenotypical patterns may relate to …
Aberrant striatal functional connectivity in children with autism
BACKGROUND:: Models of autism spectrum disorders (ASD) as neural disconnection
syndromes have been predominantly supported by examinations of abnormalities in …
syndromes have been predominantly supported by examinations of abnormalities in …
Structural-functional connectivity deficits of neocortical circuits in the Fmr1−/y mouse model of autism
Fragile X syndrome (FXS), the most common inherited form of intellectual disability disorder
and a frequent cause of autism spectrum disorder (ASD), is characterized by a high …
and a frequent cause of autism spectrum disorder (ASD), is characterized by a high …
Dysfunctional autism risk genes cause circuit-specific connectivity deficits with distinct developmental trajectories
Autism spectrum disorders (ASD) are a set of complex neurodevelopmental disorders for
which there is currently no targeted therapeutic approach. It is thought that alterations of …
which there is currently no targeted therapeutic approach. It is thought that alterations of …