Icariin stimulates osteogenesis and suppresses adipogenesis of human bone mesenchymal stem cells via miR-23a-mediated activation of the Wnt/β-catenin signaling …

Y Xu, Y Jiang, B Jia, Y Wang, T Li - Phytomedicine, 2021 - Elsevier
Background Icariin (ICA) is a bioactive compound isolated from epimedium-derived
flavonoids that modulates bone mesenchymal stem cell osteogenesis and adipogenesis …

Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway

Y Ye, X Jing, N Li, Y Wu, B Li, T Xu - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Icariin, the main active flavonoid glucoside isolated from Herba epimedii, has been
demonstrated to be a potential alternative therapy to prevent postmenopausal osteoporosis …

Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ERα-Wnt/β-catenin signaling pathway

QS Wei, J Zhang, GJ Hong, ZQ Chen, WM Deng… - Biomedicine & …, 2016 - Elsevier
Icariin, the main effective component of Herba Epimedii, has been identified to regulate the
osteogenic differentiation of rat bone marrow stromal cells (rBMSCs) and have potential …

Icariin regulates the bidirectional differentiation of bone marrow mesenchymal stem cells through canonical Wnt signaling pathway

J Huang, Y Bao, W Xiang, X Jing, J Guo… - Evidence‐Based …, 2017 - Wiley Online Library
Fat infiltration within the bone marrow is easily observed in some postmenopausal women.
Those fats are mainly derived from bone marrow mesenchymal stem cells (BMMSCs). The …

[HTML][HTML] A novel semisynthetic molecule icaritin stimulates osteogenic differentiation and inhibits adipogenesis of mesenchymal stem cells

H Sheng, X Rui, CJ Sheng, WJ Li… - … journal of medical …, 2013 - ncbi.nlm.nih.gov
Background We previously reported that the constitutional flavonoid glycosides derived from
herb Epimedium (EF, composed of seven flavonoid compounds with common nuclear stem) …

Icariin stimulates osteogenic differentiation of rat bone marrow stromal stem cells by increasing TAZ expression

QS Wei, MC He, MH Chen, ZQ Chen, F Yang… - Biomedicine & …, 2017 - Elsevier
Icariin, the major ingredient of Herba Epimedii, promotes the osteogenic differentiation of rat
bone marrow stromal cells (rBMSCs) and exerts protective effects against bone loss and …

Icariin stimulates differentiation and suppresses adipocytic transdifferentiation of primary osteoblasts through estrogen receptor-mediated pathway

D Zhang, C Fong, Z Jia, L Cui, X Yao… - Calcified tissue …, 2016 - Springer
Icariin, the main constituent of Herba Epimedii, appears to be a promising alternative to
classic drugs used to treat osteoporosis. However, the detailed molecular mechanisms of its …

Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation

L Song, J Zhao, X Zhang, H Li, Y Zhou - European journal of pharmacology, 2013 - Elsevier
Icariin, the main active flavonoid glucoside isolated from Herba epimedii (HEF), is an
anabolic agent in bone that has been reported to prevent bone loss in ovariectomized rats …

The effect of icariin on bone metabolism and its potential clinical application

Z Wang, D Wang, D Yang, W Zhen, J Zhang… - Osteoporosis …, 2018 - Springer
Osteoporosis is a bone disease characterized by reduced bone mass, which leads to
increased risk of bone fractures, and poses a significant risk to public health, especially in …

Icariin induces osteogenic differentiation of bone mesenchymal stem cells in a MAPK‐dependent manner

Y Wu, L Xia, Y Zhou, Y Xu, X Jiang - Cell Proliferation, 2015 - Wiley Online Library
Objectives Icariin, a flavonoid isolated from Epimedium pubescens, has previously been
identified to exert beneficial effects on preventing bone loss and promoting bone …