[HTML][HTML] Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases

DW Dekens, ULM Eisel, L Gouweleeuw… - Ageing research …, 2021 - Elsevier
Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …

Increased plasma levels of lipocalin 2 in mild cognitive impairment

J Choi, HW Lee, K Suk - Journal of the neurological sciences, 2011 - Elsevier
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by an irreversible cognitive decline and neuronal loss associated with …

Perspectives in Lipocalin-2: emerging biomarker for medical diagnosis and prognosis for Alzheimer's disease

J Song, OY Kim - Clinical Nutrition Research, 2018 - synapse.koreamed.org
Lipocalin-2 (LCN2), a secreted glycoprotein belonging to the lipocalin superfamily was
reported to participate in various biological processes including cell migration, cell survival …

Lipocalin 2 regulates iron homeostasis, neuroinflammation, and insulin resistance in the brains of patients with dementia: Evidence from the current literature

D Lim, J Jeong, J Song - CNS neuroscience & therapeutics, 2021 - Wiley Online Library
Dementia accompanied by memory loss is considered one of the most common
neurodegenerative diseases worldwide, and its prevalence is gradually increasing. Known …

[HTML][HTML] Lipocalin 2: novel component of proinflammatory signaling in Alzheimer's disease

PJW Naudé, C Nyakas, LE Eiden, D Ait-Ali… - The FASEB …, 2012 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is associated with an altered immune response, resulting in
chronic increased inflammatory cytokine production with a prominent role of TNF-α. TNF-α …

Role of lipocalin-2 in amyloid-beta oligomer-induced mouse model of Alzheimer's disease

H Kang, HJ Shin, HS An, Z Jin, JY Lee, J Lee, KE Kim… - Antioxidants, 2021 - mdpi.com
Lipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although
many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 …

From the periphery to the brain: Lipocalin-2, a friend or foe?

AC Ferreira, S Dá Mesquita, JC Sousa… - Progress in …, 2015 - Elsevier
Abstract Lipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded
siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the …

Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model

DW Dekens, PJW Naudé, JN Keijser… - Journal of …, 2018 - Springer
Abstract Background Lipocalin 2 (Lcn2) is an acute-phase protein implicated in multiple
neurodegenerative conditions. Interestingly, both neuroprotective and neurodegenerative …

Lipocalin-2 as a therapeutic target for brain injury: an astrocentric perspective

K Suk - Progress in neurobiology, 2016 - Elsevier
Abstract Lipocalin-2 (LCN2) is a member of the secreted lipocalin protein family. LCN2 is
also a representative gliocalin that is primarily released by glial cells, as well as acts upon …

Diverse functional roles of lipocalin-2 in the central nervous system

MK Jha, S Lee, DH Park, H Kook, KG Park… - Neuroscience & …, 2015 - Elsevier
Abstract Lipocalin-2 (LCN2) is an acute phase protein with multiple functions that has
garnered a great deal of interest over the last decade. However, its precise role in the …