Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

Emerging models of the bacterial nucleoid show that nucleoid-associated proteins (NAPs)
and transcription contribute in combination to the dynamic nature of nucleoid structure …

Nucleoid‐associated proteins (NAPs) are architectural proteins of the bacterial chromosome
and transcription factors that dynamically organise the chromosome and regulate gene …

Bacterial chromosomes are folded to compact DNA and facilitate cellular processes.
Studying model bacteria has revealed aspects of chromosome folding that are applicable to …

Highlights•Addresses the nature of the distinction between bacterial transcription factors and
nucleoid-associated proteins.•Proteins lie along a spectrum of influence extending from …

Decades of research have probed the interplay between chromatin (genomic DNA
associated with proteins and RNAs) and transcription by RNA polymerase (RNAP) in all …

All organisms must dramatically compact their genomes to accommodate DNA within the
cell. Bacteria use a set of DNA-binding proteins with low sequence specificity called …

Recent studies have revealed that the bacterial nucleoid is a dynamic entity that alters its
overall structure in response to changes in both growth rate and growth phase. These …

The bacterial chromosome must be efficiently compacted to fit inside the small and crowded
cell while remaining accessible for the protein complexes involved in replication …

Bacterial DNA is organised in a compact nucleoid body that is tightly associated with the
coupled transcription and translation of mRNAs. This structure contains abundant DNA …