OBJECTIVES: Extracorporeal membrane oxygenation is a potentially life-saving intervention
in refractory cardiopulmonary failure, but it requires anticoagulation to prevent circuit …

Introduction Extracorporeal membrane oxygenation (ECMO) after cardiac operations
(postcardiotomy) is commonly used for the treatment of acute heart failure refractory to drug …

Introduction Unfractionated heparin (UFH) is the anticoagulant of choice for extracorporeal
membrane oxygenation (ECMO), but bivalirudin can be used as an alternative. The purpose …

OBJECTIVES: Extracorporeal membrane oxygenation is a life-sustaining therapy for severe
respiratory failure. Extracorporeal membrane oxygenation circuits require systemic …

Background Extracorporeal membrane oxygenation (ECMO) induces hemostatic alterations
that may contribute to hematological complications. Unfractionated heparin (UFH) is the …

Introduction Bleeding is the most frequent complication in patients receiving venoarterial or
venovenous extracorporeal membrane oxygenation (ECMO). Recombinant activated factor …

Introduction Renal insufficiency increases the half-life of low molecular weight heparins
(LMWHs). Whether continuous venovenous hemofiltration (CVVH) removes LMWHs is …

Introduction The mechanism of coagulation activation during continuous venovenous
hemofiltration (CVVH) has not yet been elucidated. Insight into the mechanism (s) of …

Objective Bivalirudin has been suggested as an alternative to heparin for anticoagulation in
patients receiving extracorporeal membrane oxygenation (ECMO). Nevertheless, there is …

Background During venovenous extracorporeal membrane oxygenation (vvECMO), direct
thrombin inhibitors are considered by some potentially advantageous over unfractionated …