Development of an Oral Vaccine against Clostridioides difficile

C Karyal - 2021 - eprints.nottingham.ac.uk
Clostridioides difficile (C. difficile) is the leading cause of hospital acquired diarrhoeal
infection. The major risk factors associated with C. difficile infection (CDI) is age (65 and …

[HTML][HTML] Colonisation Factor CD0873, an Attractive Oral Vaccine Candidate against Clostridioides difficile

C Karyal, J Hughes, ML Kelly, JC Luckett, PV Kaye… - Microorganisms, 2021 - mdpi.com
Clostridioides difficile is the main cause of health-care-associated infectious diarrhoea.
Toxins, TcdA and TcdB, secreted by this bacterium damage colonic epithelial cells and in …

[HTML][HTML] Mucosal Vaccination Strategies against Clostridioides difficile Infection

J Heuler, H Chandra, X Sun - Vaccines, 2023 - mdpi.com
Clostridioides difficile infection (CDI) presents a major public health threat by causing
frequently recurrent, life-threatening cases of diarrhea and intestinal inflammation. The …

Status of vaccine research and development for Clostridium difficile

TV Riley, D Lyras, GR Douce - Vaccine, 2019 - Elsevier
Clostridium difficile associated disease is fundamentally associated with dysbiosis of the gut
microbiome as a consequence of antibiotic use. This is because this sporulating, obligate …

[HTML][HTML] Towards Development of a Non-Toxigenic Clostridioides difficile Oral Spore Vaccine against Toxigenic C. difficile

J Hughes, C Aston, ML Kelly, R Griffin - Pharmaceutics, 2022 - mdpi.com
Clostridioides difficile is an opportunistic gut pathogen which causes severe colitis, leading
to significant morbidity and mortality due to its toxins, TcdA and TcdB. Two intra-muscular …

Prospects for a Vaccine for Clostridium difficile

L Kyne, CP Kelly - BioDrugs, 1998 - Springer
Clostridium difficile diarrhoea and colitis is a new disease that is attributable to broad
spectrum antibiotic therapy. During the past 2 decades C. difficile has become one of the …

[HTML][HTML] Non-Toxin-Based Clostridioides difficile Vaccination Approaches

A Razim, S Górska, A Gamian - Pathogens, 2023 - mdpi.com
Clostridioides difficile (CD) is a Gram-positive, anaerobic bacterium that infects mainly
hospitalized and elderly people who have been treated with long-term antibiotic therapy …

[图书][B] Preclinical development of a novel vaccine targeting Clostridioides difficile using an attenuated Salmonella Typhimurium vector

K Winter - 2022 - search.proquest.com
Clostridioides difficile infection (CDI) is one of the most important nosocomial infections in
the world. In 2012, approximately 40,000 CDI cases were reported in Canada with a cost of …

Active and passive immunization against Clostridium difficile diarrhea and colitis

PJ Giannasca, M Warny - Vaccine, 2004 - Elsevier
Clostridium difficile, a gram-positive bacterium, is the major cause of hospital-acquired
infectious diarrhea and colitis in industrialized nations. C. difficile colonization results from …

Safety, immunogenicity, and efficacy of a Clostridioides difficile toxoid vaccine candidate: a phase 3 multicentre, observer-blind, randomised, controlled trial

G de Bruyn, DL Gordon, T Steiner… - The Lancet infectious …, 2021 - thelancet.com
Background In the absence of a licensed vaccine, Clostridioides (formerly Clostridium)
difficile infection represents a substantial health burden. The aim of this study was to …