The persistence of Mycobacterium tuberculosis (Mtb) is a major problem in managing
tuberculosis (TB). Host-generated nitric oxide (NO) is perceived as one of the signals by Mtb …

Iron-sulfur (Fe-S) biogenesis requires multiprotein assembly systems, SUF and ISC, in most
prokaryotes. M. tuberculosis (Mtb) encodes a complete SUF system, the depletion of which …

The ability of Mycobacterium tuberculosis (Mtb) to tolerate nitric oxide and superoxide
produced by phagocytes contributes to its success as a human pathogen. Recombination of• …

Tuberculosis, caused by the obligate intracellular pathogen Mycobacterium tuberculosis
(Mtb), is responsible for 2–3 million deaths annually worldwide. Intracellular adaptability …

A fundamental challenge in the redox biology of Mycobacterium tuberculosis (Mtb) is to
understand the mechanisms involved in sensing redox signals such as oxygen (O2), nitric …

All pathogenic and nonpathogenic microbes are continuously exposed to environmental or
endogenous reactive oxygen and nitrogen species, which can critically effect survival and …

Abstract Significance: Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis
(TB), can persist in a latent state for decades without causing overt disease. Since latent Mtb …

Iron-sulfur (Fe-S) cluster proteins carry out essential cellular functions in diverse organisms,
including the human pathogen Mycobacterium tuberculosis (Mtb). The mechanisms …

To successfully colonize host tissues, bacteria must respond to and detoxify many different
host-derived antimicrobial compounds, such as nitric oxide (NO). NO has direct antimicrobial …

Iron is vital metal for Mycobacterium tuberculosis infection, survival, and persistence within
its human host. The mobilization of sulphur (SUF) operon encodes the primary iron-sulphur …