Decades of neurobiological research have disclosed the diverse manners in which the
response properties of neurons are dynamically modulated to support adaptive cognitive …

The human brain exhibits a distinct spatiotemporal organization that supports brain function
and can be manipulated via local brain stimulation. Such perturbations to local cortical …

Biological neural networks produce information backgrounds of multi-scale spontaneous
activity that become more complex in brain states displaying higher capacities for cognition …

Movement, cognition and perception arise from the collective activity of neurons within
cortical circuits and across large-scale systems of the brain. While the causes of single …

How tightly tuned are the synaptic and intrinsic properties that give rise to neuron and circuit
function? Experimental work shows that these properties vary considerably across identified …

Neuromodulation underlies many behavioral states and has been extensively studied in
small circuits. This has allowed the systematic exploration of how neuromodulatory …

Technological advances have dramatically expanded our ability to probe multi-neuronal
dynamics and connectivity in the brain. However, our ability to extract a simple conceptual …

Addressing the multiscale organization of the brain, which is fundamental to the dynamic
repertoire of the organ, remains challenging. In principle, it should be possible to model …

Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …

Data-driven computational models of neurons, synapses, microcircuits, and mesocircuits
have become essential tools in modern brain research. The goal of these multiscale models …