The interaction between host and microorganism widely affects the immune and metabolic
status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan …

Indole and its derivatives are widespread across different life forms, functioning as signalling
molecules in prokaryotes and with more diverse roles in eukaryotes. A majority of indoles …

Endogenous indole and its derivatives (indoles), considered as promising N-substituted
heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and …

Background: Increasing evidence proves the pivotal role of gut microbiota in mammals'
homeostasis. Gut bacterial metabolites may exert local effects on the intestines, and may …

The intestinal microbiota metabolic activity towards the available substrates generates
myriad bacterial metabolites that may accumulate in the luminal fluid. Among them, indole …

Increasing evidence suggests that metabolites produced by the gut microbiota play a crucial
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …

Highlights•Indole-3-aldehyde (3-IAld) is a tryptophan metabolite produced by the gut
microbiota.•3-IAld regulates barrier function and immunity via the Aryl hydrocarbon …

Interactions between the gut microbiota and the host are important for health, where
dysbiosis has emerged as a likely component of mucosal disease. The specific constituents …

Indole compounds are extracted from indigo plants and have been used as blue or purple
dyes for hundreds of years. In traditional Chinese medicine, herbal agents in combination …

The gut microbiota regulates key hepatic functions, notably through the production of
bacterial metabolites that are transported via the portal circulation. We evaluated the effects …