Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic
form of regulated cell death that has been implicated in maladaptive renal repair in mice and …

Background: Ferroptosis, an iron-dependent form of regulated necrosis mediated by lipid
peroxidation, predominantly polyunsaturated fatty acids, is involved in postischemic and …

In both humans and mice, repair of acute kidney injury is worse in males than in females.
Here, we provide evidence that this sexual dimorphism results from sex differences in …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma
membrane rupture of cells in a specific section of a nephron, referred to as acute tubular …

Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

The renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including ischemia, proteinuria, toxins, and metabolic disorders. It has long been …

Renal fibrosis is a common pathological process that occurs with diverse etiologies in
chronic kidney disease. However, its regulatory mechanisms have not yet been fully …

Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Tubular injury has a major etiological role in fibrosis. For many years, this relationship has
been dominated by the perception that epithelial cells are transformed into myofibroblasts …