Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in
serotonergic neurons to produce dysphoria and potentiate drug reward; however, the circuit …

Psychiatry and clinical psychology have long been divided about the roles of nature and
nurture in the pathways to psychopathology. Some clinicians offer treatment almost entirely …

Purpose Depression poses a substantial burden worldwide. Therefore, elucidating the
pathophysiological mechanism of depression is important. Sleep disturbance and sleep …

In this study, we introduce PIGEON—a novel statistical framework for quantifying and
estimating polygenic gene-environment interaction (GxE) using a variance component …

Responses to early life adversity differ greatly across individuals. Elucidating which factors
underlie this variation can help us better understand how to improve health trajectories …

Both prenatal ethanol and early-life stress have been shown to induce reduced risk-taking
and explorative behavior as well as cognitive dysfunction in the offspring. In this study, we …

Based on both positive psychology and the gene× environment research paradigm, the
current study constructed a moderated mediation model to explore the relationship between …

Mental health problems cover a wide spectrum of diseases, including mild to moderate
anxiety, depression, alcohol/drug use disorders, as well as bipolar disorder and …

Objectives: We aimed to analyze the relationship between long working hours and
depressive and anxiety symptoms according to gender and shift work. Methods: After …

Introduction This systematic review aimed to investigate variations of reference scores for
the Pain Catastrophizing Scale (PCS) between language versions and between countries in …