In this study, a role of cell loss due to necroptosis and its linkage with pyroptosis in organ
damage under the conditions of pulmonary arterial hypertension (PAH) was examined …

Reprogramming the host cellular environment is an obligatory facet of viral pathogens to
foster their replication and perpetuation. One of such reprogramming events is the dynamic …

Introduction Extracellular cold-inducible RNA-binding protein (eCIRP) is an endogenous pro-
inflammatory mediator that exacerbates injury in inflammation and sepsis. The mechanisms …

Breast cancer (BC) is a very common cancer among women and one of the primary causes
of death in women worldwide. Because BC has different molecular subtypes, the challenges …

IMB5036 is a novel pyridazinone compound with potent cytotoxicity. In this study, we
reported its antitumour activity against pancreatic cancer and the underlying mechanism. We …

Programmed cell death (PCD) in animals mainly refers to lytic and non-lytic forms.
Disruption and integrity of the plasma membrane are considered as hallmarks of lytic and …

Necroptosis is currently attracting the attention of the scientific community for its broad
implications in inflammatory diseases and cancer. However, detecting ongoing necroptosis …

Necroptosis is a type of caspase-independent programmed cell death that has been
implicated in cancer development. Activation of the canonical necroptotic pathway is often …

Necroptosis, a recently identified programmed cell death pathway, has attracted attention as
an alternative route to target apoptosis‐resistant cancer cells. The status of the necroptosis …

Abstract The inflammatory cytokine Tumor Necrosis Factor (TNF) is an important mediator of
the innate immune response to infection. While it is known that TNF is critical to defense …