Reprogramming of H3K9me3-dependent heterochromatin is required for early development.
How H3K9me3 is involved in early human development remains, however, largely unclear …

Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …

Histone modifications are critical epigenetic indicators of chromatin state associated with
gene expression. Although the reprogramming patterns of H3K4me3 and H3K27me3 have …

The zygotic genome is transcriptionally silent immediately after fertilization. In mice, initial
activation of the zygotic genome occurs in the middle of the one-cell stage. At the mid-to-late …

Endogenous retroviruses (ERVs) have been reported to participate in pre-implantation
development of mammalian embryos. In early human embryogenesis, different ERV sub …

Sperm DNA damage is considered a predictive factor for the clinical outcomes of patients
undergoing ART. Laboratory evidence suggests that zygotes and developing embryos have …

Transition from maternal to embryonic transcriptional control is crucial for embryogenesis.
However, alternative splicing regulation during this process remains understudied. Using …

Big data is transforming biomedical research by integrating massive amounts of data from
laboratory experiments, clinical investigations, healthcare records, and the internet of things …

Analysis of single-cell microRNA is essential to reveal cell heterogeneity at the genetic level.
It raises a high demand for single-cell analytical methods because single-cell microRNA …

The toxicity evaluation system of environmental pollutants has undergone numerous
changes due to the application of new technologies. Single-cell toxicogenomics is rapidly …