Mining RNAseq data reveals dynamic metaboloepigenetic profiles in human, mouse and bovine pre-implantation embryos
Metaboloepigenetic regulation has been reported in stem cells, germ cells, and tumor cells.
Embryonic metaboloepigenetics, however, have just begun to be described. Here we …
Embryonic metaboloepigenetics, however, have just begun to be described. Here we …
scSGL: kernelized signed graph learning for single-cell gene regulatory network inference
Motivation Elucidating the topology of gene regulatory networks (GRNs) from large single-
cell RNA sequencing datasets, while effectively capturing its inherent cell-cycle …
cell RNA sequencing datasets, while effectively capturing its inherent cell-cycle …
[HTML][HTML] The non-coding genome in early human development–Recent advancements
P Paloviita, S Vuoristo - Seminars in Cell & Developmental Biology, 2022 - Elsevier
Not that long ago, the human genome was discovered to be mainly non-coding, that is
comprised of DNA sequences that do not code for proteins. The initial paradigm that non …
comprised of DNA sequences that do not code for proteins. The initial paradigm that non …
The single-cell expression profile of transposable elements and transcription factors in human early biparental and uniparental embryonic development
C Li, Y Zhang, L Leng, X Pan, D Zhao, X Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Transposable elements (TEs) and transcription factors (TFs) are involved in the precise
regulation of gene expression during the preimplantation stage. Activation of TEs is a key …
regulation of gene expression during the preimplantation stage. Activation of TEs is a key …
Long-term storage does not affect the expression profiles of mRNA and long non-coding RNA in vitrified-warmed human embryos
J Li, L Zhu, J Huang, W Liu, W Han, G Huang - Frontiers in Genetics, 2022 - frontiersin.org
Although vitrification has been widely applied in assisted reproductive technology, it is
unknown whether storage time has any impact on the mRNA and lncRNA expression …
unknown whether storage time has any impact on the mRNA and lncRNA expression …
Inferring structural and dynamical properties of gene networks from data with deep learning
F Chen, C Li - NAR Genomics and Bioinformatics, 2022 - academic.oup.com
The reconstruction of gene regulatory networks (GRNs) from data is vital in systems biology.
Although different approaches have been proposed to infer causality from data, some …
Although different approaches have been proposed to infer causality from data, some …
KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2
SH Wang, J Hao, C Zhang, FF Duan, YT Chiu… - Science China Life …, 2022 - Springer
The pluripotent state of embryonic stem cells (ESCs) is regulated by a sophisticated network
of transcription factors. High expression of KLF17 has recently been identified as a hallmark …
of transcription factors. High expression of KLF17 has recently been identified as a hallmark …
CDSImpute: An ensemble similarity imputation method for single-cell RNA sequence dropouts
Background Single-cell RNA-sequencing enables the opportunity to investigate cell
heterogeneity, discover new types of cells and to perform transcriptomic reconstruction at a …
heterogeneity, discover new types of cells and to perform transcriptomic reconstruction at a …
GDF9 concentration in embryo culture medium is linked to human embryo quality and viability
J Li, C Li, X Liu, J Yang, Q Zhang, W Han… - Journal of Assisted …, 2022 - Springer
Purpose We aimed to evaluate the link between the GDF9 concentration in day 3 human
embryo culture medium and embryo quality and viability. Methods Two independent …
embryo culture medium and embryo quality and viability. Methods Two independent …
Exploring the role of autophagy during early human embryonic development through single-cell transcriptome and methylome analyses
S Song, Q Guo, Y Zhu, P Yuan, Z Yan, L Yan… - Science China Life …, 2022 - Springer
Early human embryogenesis is a very sophisticated process due to its unique gene
regulatory network. Autophagy has been suggested to play an important role in mediating …
regulatory network. Autophagy has been suggested to play an important role in mediating …