Considerations and challenges for sex-aware drug repurposing
Sex differences are essential factors in disease etiology and manifestation in many diseases
such as cardiovascular disease, cancer, and neurodegeneration. The biological influence of …
such as cardiovascular disease, cancer, and neurodegeneration. The biological influence of …
Computational pipeline for rational drug combination screening in patient-derived cells
P Athanasiadis, A Ianevski, SS Skånland… - Data Mining Techniques …, 2022 - Springer
In many complex diseases, such as cancers, resistance to monotherapies easily occurs, and
longer-term treatment responses often require combinatorial therapies as next-line …
longer-term treatment responses often require combinatorial therapies as next-line …
Evaluating a therapeutic window for precision medicine by integrating genomic profiles and p53 network dynamics
The response variation to anti-cancer drugs originates from complex intracellular network
dynamics of cancer. Such dynamic networks present challenges to determining optimal drug …
dynamics of cancer. Such dynamic networks present challenges to determining optimal drug …
Bimodal gene expression in patients with cancer provides interpretable biomarkers for drug sensitivity
W Ba-Alawi, SK Nair, B Li, A Mammoliti, P Smirnov… - Cancer research, 2022 - AACR
Identifying biomarkers predictive of cancer cell response to drug treatment constitutes one of
the main challenges in precision oncology. Recent large-scale cancer pharmacogenomic …
the main challenges in precision oncology. Recent large-scale cancer pharmacogenomic …
Node metadata can produce predictability crossovers in network inference problems
Network inference is the process of learning the properties of complex networks from data.
Besides using information about known links in the network, node attributes and other forms …
Besides using information about known links in the network, node attributes and other forms …
Discovery of druggable cancer-specific pathways with application in acute myeloid leukemia
An individualized cancer therapy is ideally chosen to target the cancer's driving biological
pathways, but identifying such pathways is challenging because of their underlying …
pathways, but identifying such pathways is challenging because of their underlying …
Learning low degree hypergraphs
E Balkanski, O Hanguir, S Wang - Conference on Learning …, 2022 - proceedings.mlr.press
We study the problem of learning a hypergraph via edge detecting queries. In this problem,
a learner queries subsets of vertices of a hidden hypergraph and observes whether these …
a learner queries subsets of vertices of a hidden hypergraph and observes whether these …
Synthetic lethal gene pairs: Experimental approaches and predictive models
Synthetic lethality (SL) refers to a genetic interaction in which the simultaneous perturbation
of two genes leads to cell or organism death, whereas viability is maintained when only one …
of two genes leads to cell or organism death, whereas viability is maintained when only one …
Can artificial intelligence accelerate preclinical drug discovery and precision medicine?
An average cost of $314 million to $2.8 billion is associated with the development of a new
drug with a minimum development period of ten years [1]. The traditional drug discovery …
drug with a minimum development period of ten years [1]. The traditional drug discovery …
Dissecting the genome for drug response prediction
The prediction of the cancer cell lines sensitivity to a specific treatment is one of the current
challenges in precision medicine. With omics and pharmacogenomics data being available …
challenges in precision medicine. With omics and pharmacogenomics data being available …