Produced amidst the still rippling effects of a pandemic and as the world experiences the
increasing burden of global warming and a rapidly changing biosphere, the second edition …

The unique biology of Plasmodium vivax, with its ability to form latent hypnozoites in the liver
stage and the early appearance of gametocytes during blood stage infection, makes it …

Abstract The RTS, S/AS01E vaccine targets the circumsporozoite protein (CSP) of the
Plasmodium falciparum (P. falciparum) parasite. Protein microarrays were used to measure …

Background Individuals living in endemic areas acquire immunity to malaria following
repeated parasite exposure. We sought to assess the controlled human malaria infection …

Background RTS, S is the first malaria vaccine recommended for implementation among
young children at risk. However, vaccine efficacy is modest and short-lived. Antibodies play …

Background Plasmodium falciparum variant surface antigens (VSAs) contribute to malaria
pathogenesis by mediating cytoadhesion of infected red blood cells to the microvasculature …

T follicular helper (TFH) cells play a crucial role in the development of long-lived, high-
quality B cell responses after infection and vaccination. However, little is known about how …

Malaria begins when an infected mosquito injects saliva containing Plasmodium sporozoites
into the skin of a vertebrate host. Passive immunization of mice with antiserum against the …

In order to be successful in global health today, all the long-established European tropical
research institutes had to undergo a transition which can be described as “hunter-gatherer” …

Abstract The US Army Medical Research Directorate–Africa, also known as the “Walter
Reed Project,” is at the forefront of the US military's malaria research and surveillance …