DNA methylation at the fifth position of cytosine (5mC) is one of the most studied epigenetic
mechanisms essential for the control of gene expression and for many other biological …

TET proteins mediate DNA demethylation by oxidizing 5-methylcytosine to 5-
hydroxymethylcytosine (5hmC) and other oxidative derivatives. We have previously …

The tricarboxylic acid (TCA) metabolite, succinate, is a competitive inhibitor of dioxygenase
enzymes that require alpha ketoglutarate as a cofactor. One family of dioxygenases are the …

Macrophages are widely distributed in various metabolic tissues/organs and play an
essential role in the immune regulation of metabolic homeostasis. Macrophages have two …

Background RNA modifications are essential for the establishment of cellular identity.
Although increasing evidence indicates that RNA modifications regulate the innate immune …

Aims To investigate whether DNA active demethylase TET regulates the expression of tight
junction proteins in endothelial cells of the blood–brain barrier (BBB). Methods Correlations …

Reprogramming metabolism is of great therapeutic interest for reducing morbidity and
mortality during sepsis-induced critical illness. Disappointing results from randomized …

Since early in evolution, mammalian cells have been equipped with pattern recognition
receptors (PRRs) that detect the presence of pathogen-associated molecular pattern …