Development and in vivo validation of small interfering RNAs targeting NOX3 to prevent sensorineural hearing loss

G Nacher-Soler, A Marteyn, N Barenzung… - Frontiers in …, 2022 - frontiersin.org
The reactive oxygen species (ROS)-generating enzyme NOX3 has recently been implicated
in the pathophysiology of several acquired forms of sensorineural hearing loss, including …

MicroRNAs expression in response to rhNGF in epithelial corneal cells: focus on neurotrophin signaling pathway

C Compagnoni, V Zelli, A Bianchi, A Di Marco… - International Journal of …, 2022 - mdpi.com
Purpose. Nerve growth factor efficacy was demonstrated for corneal lesions treatment, and
recombinant human NGF (rhNGF) was approved for neurotrophic keratitis therapy. However …

Nucleic acid-based COVID-19 therapy targeting cytokine storms: strategies to quell the storm

MAH Abusalah, M Khalifa, MAI Al-Hatamleh… - Journal of Personalized …, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) has shaken the world and triggered drastic changes
in our lifestyle to control it. Despite the non-typical efforts, COVID-19 still thrives and plagues …

[Retracted] The Current Status of SSRP1 in Cancer: Tribulation and Road Ahead

S Jia, B Guo, L Wang, L Peng… - Journal of Healthcare …, 2022 - Wiley Online Library
Background and Objectives. Owing to the complexity and heterogeneity of tumors, cancer's
early diagnoses and treatment have become a provocation. Structure‐specific recognition …

Proteinopathies associated to repeat expansion disorders

A Fourier, I Quadrio - Journal of Neural Transmission, 2022 - Springer
The most common neurodegenerative disorders, such as Alzheimer's or Parkinson's
diseases, are characterized by synaptic dysfunction, neuronal loss and proteinaceous …

Loss of full-length pumilio 1 abrogates miRNA-221-induced gene p27 silencing-mediated cell proliferation in the heart

Y Zhou, DYE Ng, AM Richards, P Wang - Molecular Therapy-Nucleic Acids, 2022 - cell.com
Upregulated expression of microRNA (miR)-221 is associated with downregulation of p27
and subsequent increased cell proliferation in a variety of human cancers. It is unknown …

[图书][B] Applications of Nanovesicular Drug Delivery

AK Nayak, MS Hasnain, TM Aminabhavi, VP Torchilin - 2022 - books.google.com
Applications of Nanovesicular Drug Delivery provides thorough insights and a complete and
updated discussion on the preparation, properties and drug delivery applications of various …

Mineralized vectors for gene therapy

TA Dick, ED Sone, H Uludağ - Acta Biomaterialia, 2022 - Elsevier
There is an intense interest in developing materials for safe and effective delivery of
polynucleotides using non-viral vectors. Mineralization of organic templates has long been …

RNA interference: a versatile tool to augment plant protection strategies in potato

S Sundaresha, A Jeevalatha, R Kumar, S Sood… - … Management of Potato …, 2022 - Springer
Potato is one of the most important nongrain food crops grown worldwide. The potato
genome sequencing consortium has not yet identified and marked its functionality for a large …

Precision medicine shows promise to advance the care of individuals with hearing loss

M Pei, BM Colbert, MR Smeal, SH Blanton… - Medical Research …, 2022 - esmed.org
Hearing loss (HL) is the most common sensory disorder worldwide and arises from a
heterogeneous set of genetic and environmental etiologies. Currently, therapy for …