Epigenetic aging as a biomarker of dementia and related outcomes: a systematic review
Background: Biological aging may be a robust biomarker of dementia or cognitive
performance. This systematic review synthesized the evidence for an association between …
performance. This systematic review synthesized the evidence for an association between …
Association of unhealthy lifestyle and childhood adversity with acceleration of aging among UK biobank participants
G Yang, X Cao, X Li, J Zhang, C Ma, N Zhang… - JAMA Network …, 2022 - jamanetwork.com
Importance Accelerated aging makes adults more vulnerable to chronic diseases and death.
Whether childhood adversity is associated with accelerated aging processes, and to what …
Whether childhood adversity is associated with accelerated aging processes, and to what …
[HTML][HTML] DNA methylation-based measures of biological aging and cognitive decline over 16-years: preliminary longitudinal findings in midlife
DNA methylation-based (DNAm) measures of biological aging associate with increased risk
of morbidity and mortality, but their links with cognitive decline are less established. This …
of morbidity and mortality, but their links with cognitive decline are less established. This …
Low serum klotho associated with all-cause mortality among a nationally representative sample of American adults
JK Kresovich, CM Bulka - The Journals of Gerontology: Series A, 2022 - academic.oup.com
Abstract α-Klotho (klotho) is a protein involved in suppressing oxidative stress and
inflammation. In animal models, it is reported to underlie numerous aging phenotypes and …
inflammation. In animal models, it is reported to underlie numerous aging phenotypes and …
[HTML][HTML] Accelerated epigenetic aging mediates link between adverse childhood experiences and depressive symptoms in older adults: results from the Health and …
Adverse childhood experiences (ACEs) increase risk for depression at subsequent ages
and have been linked to accelerated biological aging. We hypothesize that accelerated …
and have been linked to accelerated biological aging. We hypothesize that accelerated …
The role of adolescent lifestyle habits in biological aging: A prospective twin study
Background: Adolescence is a stage of fast growth and development. Exposures during
puberty can have long-term effects on health in later life. This study aims to investigate the …
puberty can have long-term effects on health in later life. This study aims to investigate the …
Association of cardiovascular health through young adulthood with genome-wide DNA methylation patterns in midlife: the CARDIA study
Background: Cardiovascular health (CVH) from young adulthood is strongly associated with
an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining …
an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining …
[HTML][HTML] Personal airborne chemical exposure and epigenetic ageing biomarkers in healthy Chinese elderly individuals: Evidence from mixture approaches
Background Air pollution is associated with accelerated biological ages determined by DNA
methylation (DNAm) patterns, imposing further risks of age-related adverse effects …
methylation (DNAm) patterns, imposing further risks of age-related adverse effects …
An integrative machine-learning meta-analysis of high-throughput omics data identifies age-specific hallmarks of Alzheimer's disease
MN Shokhirev, AA Johnson - Ageing Research Reviews, 2022 - Elsevier
Alzheimer's disease (AD) is an incredibly complex and presently incurable age-related brain
disorder. To better understand this debilitating disease, we collated and performed a meta …
disorder. To better understand this debilitating disease, we collated and performed a meta …
Immunosenescence and altered vaccine efficiency in older subjects: A myth difficult to change
Organismal ageing is associated with many physiological changes, including differences in
the immune system of most animals. These differences are often considered to be a key …
the immune system of most animals. These differences are often considered to be a key …