Background: Older adults account for 70% of cancer-related deaths, but previous studies
have shown that they are underrepresented in cancer clinical trials. We sought to analyze …

Non-small-cell lung cancer (NSCLC) is the primary cause of cancer-related death. Gene
rearrangements involving the anaplastic lymphoma kinase (ALK) tyrosine kinase identify a …

Background: Alectinib, a highly selective inhibitor of ALK, is currently used in the first-line
setting of untreated advanced ALK-positive NSCLC and in the second-line setting of …

Simple Summary Epithelial-to-mesenchymal transition (EMT) is a cellular plasticity program
that can confer invasiveness, dissemination, and therapy resistance to cancer cells …

Lung cancer is one of the deadliest types of cancer responsible for thousands of cancer-
related deaths. Its treatment has remained a challenge for researchers, but an increase in …

Simple Summary Patients with Anaplastic lymphoma kinase (ALK)-positive lung cancer after
progression of ALK-tyrosine kinase inhibitor have limited treatment options. This study …

Anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer (NSCLC)
respond well to ALK tyrosine kinase inhibitors (TKIs), and echinoderm microtubule …

Our ability to prognosticate the clinical course of patients with cancer has historically been
limited to clinical, histopathological, and radiographic features. It has long been clear …

Sternectomy is a procedure mainly used for removing tumor masses infiltrating the sternum
or treating infections. Moreover, the removal of the sternum involves the additional challenge …

Simple Summary The growing efficacy and availability of new targeted systemic therapies
have markedly improved the prognosis of metastatic lung cancer patients harboring ALK …