Reference-based cell-type annotation can significantly reduce time and effort in single-cell
analysis by transferring labels from a previously-annotated dataset to a new dataset …

Aberrant epithelial differentiation and regeneration contribute to colon pathologies, including
inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Myeloid …

The kidney functions through the coordination of approximately one million multifunctional
nephrons in 3-dimensional space. Molecular understanding of the kidney has relied on …

Spatial transcriptomic technologies have been developed rapidly in recent years. The
addition of spatial context to expression data holds the potential to revolutionize many fields …

Metacells are cell groupings derived from single-cell sequencing data that represent highly
granular, distinct cell states. Here, we present single-cell aggregation of cell-states …

The complex determinants of health and disease can be determined when approached as a
system of interactions of biological agents at different scales. Similar to the physicochemical …

Engineering and computational advances have opened many new avenues in cancer
research, particularly when being exploited in interdisciplinary approaches. For example …

Profiling cellular heterogeneity in formalin-fixed paraffin-embedded (FFPE) tissues is key to
characterizing clinical specimens for biomarkers, therapeutic targets, and drug responses …

Currently, cancer is the leading cause of death and its incidence and mortality is growing
rapidly all over the world. One of the confounding factors contributing to the failure of …

Multiparametric imaging allows researchers to measure the expression of many biomarkers
simultaneously, allowing detailed characterization of cell microenvironments. One such …