Every profession has an essential, behind-the-scenes component without which it cannot
function. Medicine is no exception. Pathologists are one of medicine's group of specialists …

Tumors are not a simple aggregate of transformed cells but rather a complicated ecosystem
containing various components, including infiltrating immune cells, tumor-related stromal …

This review discusses the complex behaviors in diverse chemical and biochemical systems
to elucidate their commonalities and thus help develop a mesoscience methodology to …

The photoconductive antenna microprobe-based terahertz (THz) near-field scanning
microscope has proven to overcome the diffraction limit and demonstrated the potential in …

Melanoma is known as one of the most immunogenic tumours and is often characterised by
high mutation burden, neoantigen load and immune infiltrate. The application of …

Cancer stem cells (CSCs) usually account for a very small tumor cell population but play
pivotal roles in human cancer development and recurrence. A fundamental question in …

Tumour heterogeneity is one of the main characteristics of cancer and can be categorised
into inter‐or intratumour heterogeneity. This heterogeneity has been revealed as one of the …

Recent developments of single cell RNA-sequencing technologies lead to the exponential
growth of single cell sequencing datasets across different conditions. Combining these …

Comprehensive clinical, pathological, and molecular data, when appropriately integrated
with advanced computational approaches, are transforming the way we characterize and …

Cellular heterogeneity underlies cancer evolution and metastasis. Advances in single-cell
technologies such as single-cell RNA sequencing and mass cytometry have enabled …