Inflammation, Aging, and Cardiovascular Disease: JACC Review Topic of the Week

L Liberale, L Badimon, F Montecucco… - Journal of the American …, 2022 - jacc.org
Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

L Liberale, F Montecucco, JC Tardif… - European heart …, 2020 - academic.oup.com
The ongoing worldwide increase in life expectancy portends a rising prevalence of age-
related cardiovascular (CV) diseases in the coming decades that demands a deeper …

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

L Ferrucci, E Fabbri - Nature Reviews Cardiology, 2018 - nature.com
Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

[HTML][HTML] Source of chronic inflammation in aging

F Sanada, Y Taniyama, J Muratsu, R Otsu… - Frontiers in …, 2018 - frontiersin.org
Aging is a complex process that results from a combination of environmental, genetic, and
epigenetic factors. A chronic pro-inflammatory status is a pervasive feature of aging. This …

[HTML][HTML] Modern concepts in cardiovascular disease: inflamm-aging

YM Puspitasari, S Ministrini, L Schwarz… - Frontiers in cell and …, 2022 - frontiersin.org
The improvements in healthcare services and quality of life result in a longer life expectancy
and a higher number of aged individuals, who are inevitably affected by age-associated …

Unveiling the role of inflammation and oxidative stress on age‐related cardiovascular diseases

AJPO de Almeida… - Oxidative medicine …, 2020 - Wiley Online Library
The global population above 60 years has been growing exponentially in the last decades,
which is accompanied by an increase in the prevalence of age‐related chronic diseases …

Inflammation and cardiovascular disease: from pathogenesis to therapeutic target

E Golia, G Limongelli, F Natale, F Fimiani… - Current atherosclerosis …, 2014 - Springer
Atherosclerosis represents the most common pathological substrate of coronary heart
disease (CHD), and the characterization of the disease as a chronic low-grade inflammatory …

So! What's aging? Is cardiovascular aging a disease?

EG Lakatta - Journal of molecular and cellular cardiology, 2015 - Elsevier
Abstract “Inside every old person is a young person wondering what happened.” So, what is
aging? Aging is a manifestation of progressive, time-dependent failure of molecular …

[HTML][HTML] Inflammation and cardiovascular disease: From mechanisms to therapeutics

A Alfaddagh, SS Martin, TM Leucker, ED Michos… - American journal of …, 2020 - Elsevier
Inflammation constitutes a complex, highly conserved cascade of molecular and cellular
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …

[HTML][HTML] Inflammation and cardiovascular disease: the future

N Arnold, K Lechner, C Waldeyer… - European Cardiology …, 2021 - ncbi.nlm.nih.gov
Despite considerable advances in reducing the global burden of atherosclerotic
cardiovascular disease by targeting conventional risk factors, significant residual risk …